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Spyre Therapeutics, Inc.

SYRE Nasdaq Pharmaceutical Preparations Financials FY2016–FY2025

Spyre Therapeutics, Inc. had $0.0M of revenue in fiscal 2025.

Last close Β· Oct 23, 2026

$90.33

2.2%

What Spyre Therapeutics, Inc. does

SYRE Β· Pharmaceutical Preparations

From its latest annual report

No business description yet.

Filing details

Legal name
Spyre Therapeutics, Inc.
Fiscal year ends
December 31, 2025
Latest annual report
10-K Β· Feb 19, 2026
Accession Β· CIK
0001636282-26-000020 Β· 0001636282

Earnings calendar Β· Spyre Therapeutics, Inc.

Every quarter, companies publish how much they sold and earned. These are the days Spyre Therapeutics, Inc. did it, and the next one. Share prices often move a lot on those days.

Next results

November 3, 2026

Tuesday Β· in 8 days

Time
Time not announced
Covers
Period ended Sep 30, 2026
Expected EPS
βˆ’$0.79
Source
Earnings calendar
See who else reports that week β†’
Date Results for Time Source
Aug 4, 2026 Q2 '26 After the market closes 8-K β†—
Apr 13, 2026 Q1 '26 After the market closes 8-K β†—
Feb 19, 2026 Q4 '25 After the market closes 8-K β†—
Oct 14, 2025 Q3 '25 Before the market opens 8-K β†—
Aug 5, 2025 Q2 '25 After the market closes 8-K β†—
May 8, 2025 Q1 '25 After the market closes 8-K β†—
Jan 13, 2025 Q4 '24 Before the market opens 8-K β†—
Nov 7, 2024 Q3 '24 After the market closes 8-K β†—

From SEC filings: the results press release (8-K) or, without one, the quarterly or annual report.

KIRA’s summary AI analyst

Hi! I read Spyre Therapeutics, Inc.’s latest annual report (fiscal 2025). Here is what stands out:

1 to watch

Spyre Therapeutics, Inc. in 30 seconds

Good So-so Weak

Weak

Does it make a profit?

βˆ’$155M

No. It lost money last year.

Rules of thumb on reported numbers. A starting point, not a recommendation.

Key numbers, fiscal 2025

Market cap Last close times the latest diluted share count, so it is approximate.
β€”
Oct 23 close
P/E Last close divided by diluted earnings per share over the last four quarters.
β€”

Revenue

Total sales reported in the income statement.

KIRA Β· Spyre Therapeutics, Inc. had $0.0M of revenue in fiscal 2025.

See the full section β†’

Operating margin

Operating income as a share of revenue.

Net income

Profit after all expenses, interest and tax.

KIRA Β· Spyre Therapeutics, Inc. lost $155M in fiscal 2025.

See the full section β†’

Free cash flow

Cash from operations minus capital spending.

Return on capital

After-tax operating income as a share of the money invested in the business: debt plus equity, minus cash.

Sales and profit

Is it selling more, and how much does it keep?

Revenue and margins

KIRA Β· Spyre Therapeutics, Inc. had $0.0M of revenue in fiscal 2025.

In plain words: Revenue is all the money customers paid. The margins show how many cents of each dollar of sales are left over at each step: after making the product (gross), after running the business (operating) and after everything, tax included (net).

Revenue

Revenue

Margins, % of revenue

Gross Operating Net FCF

Net income and earnings per share

KIRA Β· Spyre Therapeutics, Inc. lost $155M in fiscal 2025.

Loss periods are shown in red.

In plain words: Net income is the profit left after every cost and tax. Earnings per share (EPS) splits that profit across every share, so it shows what one share earned.

Net income

Net income

Diluted EPS

Diluted EPS

Cash and shareholders

How much cash comes in, and where does it go?

Cash flow

Cash from operations minus capital spending.

In plain words: Profit on paper is not the same as cash in the bank. Free cash flow is the cash left after paying to run and maintain the business: the money it can hand back to shareholders, save or invest.

Free cash flow

Free cash flow

Cash from operations vs capital spending

Cash from operations Capital spending

Cash from operations vs capital spending

Cash from operations Capital spending

Dividends, buybacks and share count

In plain words: Companies hand cash back in two ways: dividends (cash paid to shareholders) and buybacks (buying back their own shares, so each remaining share owns a bigger slice).

Dividends and buybacks

Dividends Buybacks

Diluted shares outstanding (annual)

Insider trades

KIRA Β· In the last 12 months, insiders sold $443M of shares on the open market and bought none.

Open-market purchases and sales by officers, directors and 10% owners, from Form 4 filings. β€œPlan” marks trades under a pre-arranged Rule 10b5-1 plan.

In plain words: Insiders are the people who run or own a big part of the company. Buying with their own money can signal confidence; selling often has personal reasons, like taxes or diversifying.

Bought, 12 months

$0.0M

0 insiders

Sold, 12 months

$443M

7 insiders

Of sales under plans

9%

$42.0M

DateInsiderTradeSharesPriceValueFiling
Oct 1, 2026 Scott L BurrowsChief Financial Officer Sold plan 7,500 $91.83 $0.7M Form 4
Oct 1, 2026 Heidy King-JonesSee Remarks Sold plan 28,933 $91.03 $2.6M Form 4
Oct 1, 2026 Cameron TurtleChief Executive Officer, Director Sold plan 15,000 $92.01 $1.4M Form 4
Sep 30, 2026 Scott L BurrowsChief Financial Officer Sold plan 17,500 $89.89 $1.6M Form 4
Sep 2, 2026 Scott L BurrowsChief Financial Officer Sold plan 18,232 $89.35 $1.6M Form 4
Sep 2, 2026 Heidy King-JonesSee Remarks Sold plan 400 $90.00 $0.0M Form 4
Sep 1, 2026 Scott L BurrowsChief Financial Officer Sold plan 7,500 $87.31 $0.7M Form 4
Sep 1, 2026 Cameron TurtleChief Executive Officer, Director Sold plan 15,000 $87.29 $1.3M Form 4
Sep 1, 2026 Heidy King-JonesSee Remarks Sold plan 27,999 $87.31 $2.4M Form 4
Aug 7, 2026 Jeffrey W. AlbersDirector Sold plan 23,000 $104.53 $2.4M Form 4
Aug 3, 2026 Scott L BurrowsChief Financial Officer Sold plan 7,500 $95.57 $0.7M Form 4
Aug 3, 2026 Cameron TurtleChief Executive Officer, Director Sold plan 15,000 $95.51 $1.4M Form 4
Jul 1, 2026 Sheldon SloanChief Medical Officer Sold plan 8,334 $87.70 $0.7M Form 4
Jul 1, 2026 Scott L BurrowsChief Financial Officer Sold plan 7,500 $87.74 $0.7M Form 4
Jul 1, 2026 Cameron TurtleChief Executive Officer, Director Sold plan 15,000 $87.69 $1.3M Form 4
Jun 25, 2026 Scott L BurrowsChief Financial Officer Sold 15,000 $87.13 $1.3M Form 4
Jun 23, 2026 Fairmount Funds Management LLCDirector Sold 4,684,781 $85.31 $400M Form 4
Jun 22, 2026 Michael Thomas HendersonDirector Sold plan 20,000 $100.00 $2.0M Form 4
Jun 3, 2026 Sheldon SloanChief Medical Officer Sold plan 8,333 $75.00 $0.6M Form 4
Jun 1, 2026 Cameron TurtleChief Executive Officer, Director Sold plan 15,000 $70.43 $1.1M Form 4
Jun 1, 2026 Scott L BurrowsChief Financial Officer Sold plan 7,500 $71.06 $0.5M Form 4
May 8, 2026 Michael Thomas HendersonDirector Sold plan 80,000 $74.40 $6.0M Form 4
May 1, 2026 Scott L BurrowsChief Financial Officer Sold plan 12,500 $71.37 $0.9M Form 4
May 1, 2026 Cameron TurtleChief Executive Officer, Director Sold plan 15,000 $71.37 $1.1M Form 4
May 1, 2026 Sheldon SloanChief Medical Officer Sold plan 78,333 $71.50 $5.6M Form 4
Apr 1, 2026 Scott L BurrowsChief Financial Officer Sold plan 7,500 $49.34 $0.4M Form 4
Apr 1, 2026 Cameron TurtleChief Executive Officer, Director Sold plan 15,000 $49.33 $0.7M Form 4
Apr 1, 2026 Sheldon SloanChief Medical Officer Sold plan 7,958 $50.00 $0.4M Form 4
Mar 3, 2026 Scott L BurrowsChief Financial Officer Sold plan 2,500 $40.65 $0.1M Form 4
Mar 2, 2026 Cameron TurtleChief Executive Officer, Director Sold plan 15,000 $42.19 $0.6M Form 4
Feb 2, 2026 Cameron TurtleChief Executive Officer, Director Sold plan 15,000 $32.80 $0.5M Form 4
Jan 2, 2026 Cameron TurtleChief Executive Officer, Director Sold plan 15,000 $30.68 $0.5M Form 4
Dec 1, 2025 Cameron TurtleChief Executive Officer, Director Sold plan 15,000 $29.02 $0.4M Form 4
Nov 3, 2025 Cameron TurtleChief Executive Officer, Director Sold plan 45,000 $23.33 $1.0M Form 4

Financial health

Can it carry its debts, and how well does it use its money?

Balance sheet

Cash, debt and the ratios that show how comfortably Spyre Therapeutics, Inc. can carry it.

In plain words: What the company owns and what it owes. More cash than debt is a cushion for bad times; a lot of debt leaves less room when business slows down.

Cash vs debt (incl. leases)

Cash Debt
Fiscal year endFY21FY22FY23FY24FY25
Cash and short-term investments $93.1M$55.7M$339M$603M$757M
Current ratio 4.9x4.2x10.7x11.3x13.3x
Quick ratio 4.9x4.2x10.7x11.3x13.3x
Total assets $110M$71.1M$342M$608M$778M
Total liabilities $26.0M$20.8M$73.3M$90.7M$62.5M
Shareholders' equity $83.9M$50.3M$184M$518M$715M
Net debt (βˆ’ = net cash) β€”β€”β€”β€”β€”

Returns on capital

After-tax operating income as a share of the money invested in the business: debt plus equity, minus cash.

In plain words: How much profit the business makes on the money put into it. A higher percentage means each dollar invested works harder.

Return on capital, equity and assets (annual)

Return on capital Return on equity Return on assets

Piotroski F-score

Nine pass/fail tests of profitability, funding and efficiency. 8–9 is strong, 0–2 weak.

In plain words: Nine yes/no tests of financial health, one point each. A green tick is a pass: 7 to 9 points is solid, 0 to 3 is weak.

TestFY16FY17FY18FY19FY20FY21FY22FY23FY24FY25
Net income is positive βœ• βœ• βœ• βœ• βœ• βœ• βœ• βœ• βœ• βœ•
Cash from operations is positive βœ• βœ• βœ• βœ• βœ• βœ• βœ• βœ• βœ• βœ•
Return on assets rose β€” βœ• βœ• βœ• βœ“ βœ• βœ• βœ“ βœ“ βœ“
Cash from operations exceeds net income βœ“ βœ“ βœ“ βœ“ βœ“ βœ“ βœ“ βœ“ βœ“ βœ•
Debt fell relative to assets β€” β€” β€” β€” β€” β€” β€” β€” β€” β€”
Current ratio rose β€” βœ• βœ• βœ• βœ“ βœ• βœ• βœ“ βœ“ βœ“
Share count didn't rise β€” βœ• βœ• βœ• βœ• βœ“ βœ• βœ• β€” β€”
Gross margin rose β€” β€” β€” β€” β€” β€” β€” β€” β€” β€”
Revenue rose relative to assets β€” βœ“ βœ• βœ• βœ• βœ“ βœ• βœ• βœ• βœ•
F-score β€” / 32 / 71 / 71 / 73 / 73 / 71 / 73 / 7β€” / 6β€” / 6
Accruals ratio βˆ’4.3%βˆ’4.3%βˆ’18.2%βˆ’15.6%βˆ’4.2%βˆ’8.9%βˆ’4.1%βˆ’115.7%βˆ’10.7%2.0%
Altman Z'' 17.857.453.64βˆ’6.983.20βˆ’6.06βˆ’20.59βˆ’3.484.4611.54

All figures

Every number, year by year.

10 years of figures

Amounts in USD. Hover a ratio’s name for its definition.

In plain words: Every number we have, year by year. Download it as a spreadsheet if you want to dig deeper.

Download CSV
Fiscal yearFY16FY17FY18FY19FY20FY21FY22FY23FY24FY25
Income statement
Revenue $4.6M $5.2M $3.9M $0.0M $0.0M $18.7M $2.3M $0.9M $0.0M $0.0M
Research and development $18.1M $22.8M $36.7M $64.6M $59.6M $57.1M $58.6M $89.5M $163M $172M
Operating income βˆ’$21.9M βˆ’$27.7M βˆ’$45.5M βˆ’$80.3M βˆ’$81.5M βˆ’$65.6M βˆ’$84.8M βˆ’$242M βˆ’$209M βˆ’$210M
Pretax income β€” β€” β€” βˆ’$78.3M βˆ’$80.9M βˆ’$65.7M βˆ’$84.0M βˆ’$339M βˆ’$208M βˆ’$155M
Income tax $0.0M $0.0M $0.0M $0.0M $0.0M $0.1M βˆ’$0.1M βˆ’$0.0M $0.1M βˆ’$0.0M
Net income βˆ’$21.7M βˆ’$27.2M βˆ’$44.3M βˆ’$78.3M βˆ’$80.9M βˆ’$65.8M βˆ’$83.8M βˆ’$339M βˆ’$208M βˆ’$155M
Net income to common βˆ’$21.7M βˆ’$27.2M β€” β€” β€” β€” β€” β€” β€” β€”
Diluted EPS βˆ’$2.22 βˆ’$1.80 βˆ’$2.13 βˆ’$2.45 βˆ’$1.52 βˆ’$25.02 βˆ’$24.86 $13.76 β€” β€”
Diluted shares 0.01B 0.02B 0.02B 0.03B 0.05B 0.00B 0.00B 0.01B β€” β€”
Cash flow
Cash from operations βˆ’$18.8M βˆ’$24.6M βˆ’$32.2M βˆ’$65.7M βˆ’$75.8M βˆ’$53.7M βˆ’$80.1M βˆ’$99.9M βˆ’$157M βˆ’$169M
Capital expenditure $0.2M $0.6M $0.4M $1.5M $4.3M $0.6M $0.0M $0.0M $0.0M β€”
Free cash flow βˆ’$19.1M βˆ’$25.2M βˆ’$32.6M βˆ’$67.2M βˆ’$80.1M βˆ’$54.3M βˆ’$80.2M βˆ’$99.9M βˆ’$157M β€”
Depreciation and amortization $0.1M $0.2M $0.3M $0.4M $1.0M $1.6M $1.6M $0.7M $0.0M $0.0M
Stock-based compensation $1.2M $2.5M $4.3M $4.9M $6.3M $8.0M $7.1M $25.7M $44.8M $37.6M
Balance sheet
Cash and short-term investments $63.5M $50.3M $74.5M $71.9M $146M $93.1M $55.7M $339M $603M $757M
Finance lease liabilities β€” β€” β€” $0.1M $0.1M $0.4M $0.0M β€” β€” β€”
Current assets $66.4M $55.0M $76.7M $74.5M $150M $98.9M $62.3M $342M $608M $778M
Current liabilities $4.0M $5.6M $10.2M $18.4M $16.4M $20.1M $14.7M $32.0M $54.1M $58.7M
Property and equipment, net $0.6M $0.9M $1.0M $2.4M $5.6M $4.5M $3.2M $0.0M β€” β€”
Total assets $67.1M $56.1M $77.7M $83.2M $162M $110M $71.1M $342M $608M $778M
Total liabilities $4.1M $5.7M $10.3M $23.1M $21.8M $26.0M $20.8M $73.3M $90.7M $62.5M
Preferred stock β€” β€” β€” β€” β€” $0.0M $0.0M β€” β€” β€”
Shareholders' equity $63.0M $50.3M $67.4M $60.1M $140M $83.9M $50.3M $184M $518M $715M
Margins
Operating margin βˆ’473.3% βˆ’531.7% βˆ’1,169.3% β€” β€” βˆ’350.3% βˆ’3,640.2% βˆ’27,348.0% β€” β€”
EBITDA margin βˆ’470.5% βˆ’526.9% βˆ’1,161.8% β€” β€” βˆ’341.9% βˆ’3,572.9% βˆ’27,264.0% β€” β€”
Net margin βˆ’468.8% βˆ’523.3% βˆ’1,140.6% β€” β€” βˆ’351.1% βˆ’3,598.8% βˆ’38,238.1% β€” β€”
FCF margin βˆ’411.7% βˆ’484.8% βˆ’838.9% β€” β€” βˆ’289.7% βˆ’3,442.8% βˆ’11,276.5% β€” β€”
Returns
Return on capital employed βˆ’34.7% βˆ’54.9% βˆ’67.4% βˆ’123.9% βˆ’56.1% βˆ’73.1% βˆ’150.1% βˆ’78.2% βˆ’37.6% βˆ’29.1%
Return on equity βˆ’34.5% βˆ’48.1% βˆ’75.3% βˆ’122.7% βˆ’80.9% βˆ’58.8% βˆ’124.9% βˆ’289.2% βˆ’59.3% βˆ’25.2%
Return on assets βˆ’32.4% βˆ’44.2% βˆ’66.3% βˆ’97.3% βˆ’66.1% βˆ’48.5% βˆ’92.6% βˆ’164.1% βˆ’43.8% βˆ’22.4%
Return on tangible equity βˆ’34.5% βˆ’54.1% βˆ’65.8% βˆ’130.2% βˆ’57.9% βˆ’78.4% βˆ’166.6% βˆ’184.1% βˆ’40.2% βˆ’21.7%
Growth
Revenue growth β€” 12.5% βˆ’25.3% βˆ’100.0% β€” β€” βˆ’87.6% βˆ’62.0% βˆ’100.0% β€”
Share count change β€” 54.5% 37.6% 53.4% 67.0% βˆ’95.1% 28.2% 104.6% β€” β€”
Financial health
Current ratio 16.8x 9.8x 7.5x 4.1x 9.1x 4.9x 4.2x 10.7x 11.3x 13.3x
Quick ratio 16.8x 9.8x 7.5x 4.1x 9.1x 4.9x 4.2x 10.7x 11.3x 13.3x
Capital allocation
Capex / revenue 4.6% 11.9% 10.9% β€” β€” 3.1% 1.6% 0.0% β€” β€”
Stock comp / revenue 26.4% 47.9% 110.1% β€” β€” 42.9% 305.3% 2,897.9% β€” β€”
Quality scores
Piotroski F-score β€” 2.0 1.0 1.0 3.0 3.0 1.0 3.0 β€” β€”
Altman Z'' 17.9 7.5 3.6 βˆ’7.0 3.2 βˆ’6.1 βˆ’20.6 βˆ’3.5 4.5 11.5
Accruals ratio βˆ’4.3% βˆ’4.3% βˆ’18.2% βˆ’15.6% βˆ’4.2% βˆ’8.9% βˆ’4.1% βˆ’115.7% βˆ’10.7% 2.0%

Source: SEC EDGAR XBRL filings (CIK 0001636282). Data updated October 24, 2026. Quarterly fourth quarters are the full year minus the first nine months. For information only β€” not investment advice. Check the original filings before relying on any figure.

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