1.Sales and profit
See section β- Spyre Therapeutics, Inc. had $0.0M of revenue in fiscal 2025.
- Spyre Therapeutics, Inc. lost $155M in fiscal 2025.
SYRE Nasdaq Pharmaceutical Preparations Financials FY2016βFY2025
Spyre Therapeutics, Inc. had $0.0M of revenue in fiscal 2025.
Last close Β· Oct 23, 2026
$90.33
2.2%Hi! I read Spyre Therapeutics, Inc.βs latest annual report (fiscal 2025). Here is what stands out:
Good So-so Weak
Does it make a profit?
β$155M
No. It lost money last year.
Rules of thumb on reported numbers. A starting point, not a recommendation.
Is it selling more, and how much does it keep?
KIRA Β· Spyre Therapeutics, Inc. had $0.0M of revenue in fiscal 2025.
In plain words: Revenue is all the money customers paid. The margins show how many cents of each dollar of sales are left over at each step: after making the product (gross), after running the business (operating) and after everything, tax included (net).
Revenue
Revenue
Margins, % of revenue
KIRA Β· Spyre Therapeutics, Inc. lost $155M in fiscal 2025.
Loss periods are shown in red.
In plain words: Net income is the profit left after every cost and tax. Earnings per share (EPS) splits that profit across every share, so it shows what one share earned.
Net income
Net income
Diluted EPS
Diluted EPS
How much cash comes in, and where does it go?
Cash from operations minus capital spending.
In plain words: Profit on paper is not the same as cash in the bank. Free cash flow is the cash left after paying to run and maintain the business: the money it can hand back to shareholders, save or invest.
Free cash flow
Free cash flow
Cash from operations vs capital spending
Cash from operations vs capital spending
In plain words: Companies hand cash back in two ways: dividends (cash paid to shareholders) and buybacks (buying back their own shares, so each remaining share owns a bigger slice).
Dividends and buybacks
Diluted shares outstanding (annual)
KIRA Β· In the last 12 months, insiders sold $443M of shares on the open market and bought none.
Open-market purchases and sales by officers, directors and 10% owners, from Form 4 filings. βPlanβ marks trades under a pre-arranged Rule 10b5-1 plan.
In plain words: Insiders are the people who run or own a big part of the company. Buying with their own money can signal confidence; selling often has personal reasons, like taxes or diversifying.
Bought, 12 months
$0.0M
0 insiders
Sold, 12 months
$443M
7 insiders
Of sales under plans
9%
$42.0M
| Date | Insider | Trade | Shares | Price | Value | Filing |
|---|---|---|---|---|---|---|
| Oct 1, 2026 | Scott L BurrowsChief Financial Officer | Sold plan | 7,500 | $91.83 | $0.7M | Form 4 |
| Oct 1, 2026 | Heidy King-JonesSee Remarks | Sold plan | 28,933 | $91.03 | $2.6M | Form 4 |
| Oct 1, 2026 | Cameron TurtleChief Executive Officer, Director | Sold plan | 15,000 | $92.01 | $1.4M | Form 4 |
| Sep 30, 2026 | Scott L BurrowsChief Financial Officer | Sold plan | 17,500 | $89.89 | $1.6M | Form 4 |
| Sep 2, 2026 | Scott L BurrowsChief Financial Officer | Sold plan | 18,232 | $89.35 | $1.6M | Form 4 |
| Sep 2, 2026 | Heidy King-JonesSee Remarks | Sold plan | 400 | $90.00 | $0.0M | Form 4 |
| Sep 1, 2026 | Scott L BurrowsChief Financial Officer | Sold plan | 7,500 | $87.31 | $0.7M | Form 4 |
| Sep 1, 2026 | Cameron TurtleChief Executive Officer, Director | Sold plan | 15,000 | $87.29 | $1.3M | Form 4 |
| Sep 1, 2026 | Heidy King-JonesSee Remarks | Sold plan | 27,999 | $87.31 | $2.4M | Form 4 |
| Aug 7, 2026 | Jeffrey W. AlbersDirector | Sold plan | 23,000 | $104.53 | $2.4M | Form 4 |
| Aug 3, 2026 | Scott L BurrowsChief Financial Officer | Sold plan | 7,500 | $95.57 | $0.7M | Form 4 |
| Aug 3, 2026 | Cameron TurtleChief Executive Officer, Director | Sold plan | 15,000 | $95.51 | $1.4M | Form 4 |
| Jul 1, 2026 | Sheldon SloanChief Medical Officer | Sold plan | 8,334 | $87.70 | $0.7M | Form 4 |
| Jul 1, 2026 | Scott L BurrowsChief Financial Officer | Sold plan | 7,500 | $87.74 | $0.7M | Form 4 |
| Jul 1, 2026 | Cameron TurtleChief Executive Officer, Director | Sold plan | 15,000 | $87.69 | $1.3M | Form 4 |
| Jun 25, 2026 | Scott L BurrowsChief Financial Officer | Sold | 15,000 | $87.13 | $1.3M | Form 4 |
| Jun 23, 2026 | Fairmount Funds Management LLCDirector | Sold | 4,684,781 | $85.31 | $400M | Form 4 |
| Jun 22, 2026 | Michael Thomas HendersonDirector | Sold plan | 20,000 | $100.00 | $2.0M | Form 4 |
| Jun 3, 2026 | Sheldon SloanChief Medical Officer | Sold plan | 8,333 | $75.00 | $0.6M | Form 4 |
| Jun 1, 2026 | Cameron TurtleChief Executive Officer, Director | Sold plan | 15,000 | $70.43 | $1.1M | Form 4 |
| Jun 1, 2026 | Scott L BurrowsChief Financial Officer | Sold plan | 7,500 | $71.06 | $0.5M | Form 4 |
| May 8, 2026 | Michael Thomas HendersonDirector | Sold plan | 80,000 | $74.40 | $6.0M | Form 4 |
| May 1, 2026 | Scott L BurrowsChief Financial Officer | Sold plan | 12,500 | $71.37 | $0.9M | Form 4 |
| May 1, 2026 | Cameron TurtleChief Executive Officer, Director | Sold plan | 15,000 | $71.37 | $1.1M | Form 4 |
| May 1, 2026 | Sheldon SloanChief Medical Officer | Sold plan | 78,333 | $71.50 | $5.6M | Form 4 |
| Apr 1, 2026 | Scott L BurrowsChief Financial Officer | Sold plan | 7,500 | $49.34 | $0.4M | Form 4 |
| Apr 1, 2026 | Cameron TurtleChief Executive Officer, Director | Sold plan | 15,000 | $49.33 | $0.7M | Form 4 |
| Apr 1, 2026 | Sheldon SloanChief Medical Officer | Sold plan | 7,958 | $50.00 | $0.4M | Form 4 |
| Mar 3, 2026 | Scott L BurrowsChief Financial Officer | Sold plan | 2,500 | $40.65 | $0.1M | Form 4 |
| Mar 2, 2026 | Cameron TurtleChief Executive Officer, Director | Sold plan | 15,000 | $42.19 | $0.6M | Form 4 |
| Feb 2, 2026 | Cameron TurtleChief Executive Officer, Director | Sold plan | 15,000 | $32.80 | $0.5M | Form 4 |
| Jan 2, 2026 | Cameron TurtleChief Executive Officer, Director | Sold plan | 15,000 | $30.68 | $0.5M | Form 4 |
| Dec 1, 2025 | Cameron TurtleChief Executive Officer, Director | Sold plan | 15,000 | $29.02 | $0.4M | Form 4 |
| Nov 3, 2025 | Cameron TurtleChief Executive Officer, Director | Sold plan | 45,000 | $23.33 | $1.0M | Form 4 |
Can it carry its debts, and how well does it use its money?
Cash, debt and the ratios that show how comfortably Spyre Therapeutics, Inc. can carry it.
In plain words: What the company owns and what it owes. More cash than debt is a cushion for bad times; a lot of debt leaves less room when business slows down.
Cash vs debt (incl. leases)
| Fiscal year end | FY21 | FY22 | FY23 | FY24 | FY25 |
|---|---|---|---|---|---|
| Cash and short-term investments | $93.1M | $55.7M | $339M | $603M | $757M |
| Current ratio | 4.9x | 4.2x | 10.7x | 11.3x | 13.3x |
| Quick ratio | 4.9x | 4.2x | 10.7x | 11.3x | 13.3x |
| Total assets | $110M | $71.1M | $342M | $608M | $778M |
| Total liabilities | $26.0M | $20.8M | $73.3M | $90.7M | $62.5M |
| Shareholders' equity | $83.9M | $50.3M | $184M | $518M | $715M |
| Net debt (β = net cash) | β | β | β | β | β |
After-tax operating income as a share of the money invested in the business: debt plus equity, minus cash.
In plain words: How much profit the business makes on the money put into it. A higher percentage means each dollar invested works harder.
Return on capital, equity and assets (annual)
Nine pass/fail tests of profitability, funding and efficiency. 8β9 is strong, 0β2 weak.
In plain words: Nine yes/no tests of financial health, one point each. A green tick is a pass: 7 to 9 points is solid, 0 to 3 is weak.
| Test | FY16 | FY17 | FY18 | FY19 | FY20 | FY21 | FY22 | FY23 | FY24 | FY25 |
|---|---|---|---|---|---|---|---|---|---|---|
| Net income is positive | β | β | β | β | β | β | β | β | β | β |
| Cash from operations is positive | β | β | β | β | β | β | β | β | β | β |
| Return on assets rose | β | β | β | β | β | β | β | β | β | β |
| Cash from operations exceeds net income | β | β | β | β | β | β | β | β | β | β |
| Debt fell relative to assets | β | β | β | β | β | β | β | β | β | β |
| Current ratio rose | β | β | β | β | β | β | β | β | β | β |
| Share count didn't rise | β | β | β | β | β | β | β | β | β | β |
| Gross margin rose | β | β | β | β | β | β | β | β | β | β |
| Revenue rose relative to assets | β | β | β | β | β | β | β | β | β | β |
| F-score | β / 3 | 2 / 7 | 1 / 7 | 1 / 7 | 3 / 7 | 3 / 7 | 1 / 7 | 3 / 7 | β / 6 | β / 6 |
| Accruals ratio | β4.3% | β4.3% | β18.2% | β15.6% | β4.2% | β8.9% | β4.1% | β115.7% | β10.7% | 2.0% |
| Altman Z'' | 17.85 | 7.45 | 3.64 | β6.98 | 3.20 | β6.06 | β20.59 | β3.48 | 4.46 | 11.54 |
Every number, year by year.
Amounts in USD. Hover a ratioβs name for its definition.
In plain words: Every number we have, year by year. Download it as a spreadsheet if you want to dig deeper.
| Fiscal year | FY16 | FY17 | FY18 | FY19 | FY20 | FY21 | FY22 | FY23 | FY24 | FY25 |
|---|---|---|---|---|---|---|---|---|---|---|
| Income statement | ||||||||||
| Revenue | $4.6M | $5.2M | $3.9M | $0.0M | $0.0M | $18.7M | $2.3M | $0.9M | $0.0M | $0.0M |
| Research and development | $18.1M | $22.8M | $36.7M | $64.6M | $59.6M | $57.1M | $58.6M | $89.5M | $163M | $172M |
| Operating income | β$21.9M | β$27.7M | β$45.5M | β$80.3M | β$81.5M | β$65.6M | β$84.8M | β$242M | β$209M | β$210M |
| Pretax income | β | β | β | β$78.3M | β$80.9M | β$65.7M | β$84.0M | β$339M | β$208M | β$155M |
| Income tax | $0.0M | $0.0M | $0.0M | $0.0M | $0.0M | $0.1M | β$0.1M | β$0.0M | $0.1M | β$0.0M |
| Net income | β$21.7M | β$27.2M | β$44.3M | β$78.3M | β$80.9M | β$65.8M | β$83.8M | β$339M | β$208M | β$155M |
| Net income to common | β$21.7M | β$27.2M | β | β | β | β | β | β | β | β |
| Diluted EPS | β$2.22 | β$1.80 | β$2.13 | β$2.45 | β$1.52 | β$25.02 | β$24.86 | $13.76 | β | β |
| Diluted shares | 0.01B | 0.02B | 0.02B | 0.03B | 0.05B | 0.00B | 0.00B | 0.01B | β | β |
| Cash flow | ||||||||||
| Cash from operations | β$18.8M | β$24.6M | β$32.2M | β$65.7M | β$75.8M | β$53.7M | β$80.1M | β$99.9M | β$157M | β$169M |
| Capital expenditure | $0.2M | $0.6M | $0.4M | $1.5M | $4.3M | $0.6M | $0.0M | $0.0M | $0.0M | β |
| Free cash flow | β$19.1M | β$25.2M | β$32.6M | β$67.2M | β$80.1M | β$54.3M | β$80.2M | β$99.9M | β$157M | β |
| Depreciation and amortization | $0.1M | $0.2M | $0.3M | $0.4M | $1.0M | $1.6M | $1.6M | $0.7M | $0.0M | $0.0M |
| Stock-based compensation | $1.2M | $2.5M | $4.3M | $4.9M | $6.3M | $8.0M | $7.1M | $25.7M | $44.8M | $37.6M |
| Balance sheet | ||||||||||
| Cash and short-term investments | $63.5M | $50.3M | $74.5M | $71.9M | $146M | $93.1M | $55.7M | $339M | $603M | $757M |
| Finance lease liabilities | β | β | β | $0.1M | $0.1M | $0.4M | $0.0M | β | β | β |
| Current assets | $66.4M | $55.0M | $76.7M | $74.5M | $150M | $98.9M | $62.3M | $342M | $608M | $778M |
| Current liabilities | $4.0M | $5.6M | $10.2M | $18.4M | $16.4M | $20.1M | $14.7M | $32.0M | $54.1M | $58.7M |
| Property and equipment, net | $0.6M | $0.9M | $1.0M | $2.4M | $5.6M | $4.5M | $3.2M | $0.0M | β | β |
| Total assets | $67.1M | $56.1M | $77.7M | $83.2M | $162M | $110M | $71.1M | $342M | $608M | $778M |
| Total liabilities | $4.1M | $5.7M | $10.3M | $23.1M | $21.8M | $26.0M | $20.8M | $73.3M | $90.7M | $62.5M |
| Preferred stock | β | β | β | β | β | $0.0M | $0.0M | β | β | β |
| Shareholders' equity | $63.0M | $50.3M | $67.4M | $60.1M | $140M | $83.9M | $50.3M | $184M | $518M | $715M |
| Margins | ||||||||||
| Operating margin | β473.3% | β531.7% | β1,169.3% | β | β | β350.3% | β3,640.2% | β27,348.0% | β | β |
| EBITDA margin | β470.5% | β526.9% | β1,161.8% | β | β | β341.9% | β3,572.9% | β27,264.0% | β | β |
| Net margin | β468.8% | β523.3% | β1,140.6% | β | β | β351.1% | β3,598.8% | β38,238.1% | β | β |
| FCF margin | β411.7% | β484.8% | β838.9% | β | β | β289.7% | β3,442.8% | β11,276.5% | β | β |
| Returns | ||||||||||
| Return on capital employed | β34.7% | β54.9% | β67.4% | β123.9% | β56.1% | β73.1% | β150.1% | β78.2% | β37.6% | β29.1% |
| Return on equity | β34.5% | β48.1% | β75.3% | β122.7% | β80.9% | β58.8% | β124.9% | β289.2% | β59.3% | β25.2% |
| Return on assets | β32.4% | β44.2% | β66.3% | β97.3% | β66.1% | β48.5% | β92.6% | β164.1% | β43.8% | β22.4% |
| Return on tangible equity | β34.5% | β54.1% | β65.8% | β130.2% | β57.9% | β78.4% | β166.6% | β184.1% | β40.2% | β21.7% |
| Growth | ||||||||||
| Revenue growth | β | 12.5% | β25.3% | β100.0% | β | β | β87.6% | β62.0% | β100.0% | β |
| Share count change | β | 54.5% | 37.6% | 53.4% | 67.0% | β95.1% | 28.2% | 104.6% | β | β |
| Financial health | ||||||||||
| Current ratio | 16.8x | 9.8x | 7.5x | 4.1x | 9.1x | 4.9x | 4.2x | 10.7x | 11.3x | 13.3x |
| Quick ratio | 16.8x | 9.8x | 7.5x | 4.1x | 9.1x | 4.9x | 4.2x | 10.7x | 11.3x | 13.3x |
| Capital allocation | ||||||||||
| Capex / revenue | 4.6% | 11.9% | 10.9% | β | β | 3.1% | 1.6% | 0.0% | β | β |
| Stock comp / revenue | 26.4% | 47.9% | 110.1% | β | β | 42.9% | 305.3% | 2,897.9% | β | β |
| Quality scores | ||||||||||
| Piotroski F-score | β | 2.0 | 1.0 | 1.0 | 3.0 | 3.0 | 1.0 | 3.0 | β | β |
| Altman Z'' | 17.9 | 7.5 | 3.6 | β7.0 | 3.2 | β6.1 | β20.6 | β3.5 | 4.5 | 11.5 |
| Accruals ratio | β4.3% | β4.3% | β18.2% | β15.6% | β4.2% | β8.9% | β4.1% | β115.7% | β10.7% | 2.0% |
Source: SEC EDGAR XBRL filings (CIK 0001636282). Data updated October 24, 2026. Quarterly fourth quarters are the full year minus the first nine months. For information only β not investment advice. Check the original filings before relying on any figure.