Amylyx Pharmaceuticals, Inc.
AMLX Nasdaq Pharmaceutical Preparations Financials FY2021–FY2025
Revenue
Total sales reported in the income statement.
$0.0M
100.0%
vs prior year
Operating margin
Operating income as a share of revenue.
—
Net income
Profit after all expenses, interest and tax.
−$145M
Free cash flow
Cash from operations minus capital spending.
−$123M
Return on capital
After-tax operating income as a share of the money invested in the business: debt plus equity, minus cash.
—
Market cap
Last close times the latest diluted share count, so it is approximate.
—
P/E
Last close divided by diluted earnings per share over the last four quarters.
—
On −$1.41 EPS (TTM)
What Amylyx Pharmaceuticals, Inc. does
No business description yet.
- Legal name
- Amylyx Pharmaceuticals, Inc.
- Fiscal year ends
- December 31, 2025
- Latest annual report
- 10-K · Mar 3, 2026
- Accession · CIK
- 0001193125-26-086645
0001658551
Revenue and margins
Amylyx Pharmaceuticals, Inc. had $0.0M of revenue in fiscal 2025, down 100.0% on the year before.
FY21
Revenue $0.3M
FY22
Revenue $22.2M
FY23
Revenue $381M
FY24
Revenue $87.4M
FY25
Revenue $0.0M
Q3 '23
Revenue $103M
Q4 '23
Revenue $108M
Q1 '24
Revenue $88.6M
Q2 '24
Revenue −$1.0M
Q3 '24
Revenue $0.4M
Q4 '24
Revenue −$0.7M
Q1 '25
Revenue $0.0M
Q2 '25
Revenue $0.0M
Q3 '25
Revenue $0.0M
Q4 '25
Revenue $0.0M
Q1 '26
Revenue —
Q2 '26
Revenue —
FY21
Gross —
Operating −29,013.3%
Net −30,853.0%
FCF −26,369.1%
FY22
Gross 86.5%
Operating −905.7%
Net −892.4%
FCF −820.5%
FY23
Gross 93.3%
Operating 10.2%
Net 12.9%
FCF 2.8%
FY24
Gross 93.2%
Operating −360.2%
Net −345.4%
FCF −192.1%
FY25
Gross —
Operating —
Net —
FCF —
Gross
Operating
Net
FCF
Q3 '23
Gross 94.9%
Operating 18.2%
Net 20.3%
FCF −5.4%
Q4 '23
Gross 91.4%
Operating 1.8%
Net 4.4%
FCF 12.2%
Q1 '24
Gross 93.3%
Operating −137.8%
Net −134.0%
FCF −0.6%
Q2 '24
Gross 100.8%
Operating 7,457.1%
Net 7,106.5%
FCF 6,517.0%
Q3 '24
Gross 100.0%
Operating −18,187.7%
Net −17,476.9%
FCF −9,988.2%
Q4 '24
Gross 100.0%
Operating 6,113.4%
Net 5,646.0%
FCF 8,876.4%
Q1 '25
Gross —
Operating —
Net —
FCF —
Q2 '25
Gross —
Operating —
Net —
FCF —
Q3 '25
Gross —
Operating —
Net —
FCF —
Q4 '25
Gross —
Operating —
Net —
FCF —
Q1 '26
Gross —
Operating —
Net —
FCF —
Q2 '26
Gross —
Operating —
Net —
FCF —
Gross
Operating
Net
FCF
Net income and earnings per share
Loss periods are shown in red.
FY21
Net income −$87.9M
FY22
Net income −$198M
FY23
Net income $49.3M
FY24
Net income −$302M
FY25
Net income −$145M
Q3 '23
Net income $20.9M
Q4 '23
Net income $4.7M
Q1 '24
Net income −$119M
Q2 '24
Net income −$72.7M
Q3 '24
Net income −$72.7M
Q4 '24
Net income −$37.5M
Q1 '25
Net income −$35.9M
Q2 '25
Net income −$41.4M
Q3 '25
Net income −$34.4M
Q4 '25
Net income −$33.0M
Q1 '26
Net income −$41.3M
Q2 '26
Net income −$43.4M
FY21
Diluted EPS −$13.35
FY22
Diluted EPS −$3.39
FY23
Diluted EPS $0.70
FY24
Diluted EPS −$4.43
FY25
Diluted EPS −$1.53
Q3 '23
Diluted EPS $0.30
Q4 '23
Diluted EPS $0.07
Q1 '24
Diluted EPS −$1.75
Q2 '24
Diluted EPS −$1.07
Q3 '24
Diluted EPS −$1.07
Q4 '24
Diluted EPS −$0.54
Q1 '25
Diluted EPS −$0.42
Q2 '25
Diluted EPS −$0.46
Q3 '25
Diluted EPS −$0.37
Q4 '25
Diluted EPS −$0.28
Q1 '26
Diluted EPS −$0.37
Q2 '26
Diluted EPS −$0.39
Returns on capital
After-tax operating income as a share of the money invested in the business: debt plus equity, minus cash.
FY21
Return on capital —
Return on equity —
Return on assets −83.3%
FY22
Return on capital —
Return on equity −209.4%
Return on assets −79.8%
FY23
Return on capital —
Return on equity 12.7%
Return on assets 10.8%
FY24
Return on capital —
Return on equity −100.9%
Return on assets −84.9%
FY25
Return on capital —
Return on equity −61.6%
Return on assets −55.0%
Return on capital
Return on equity
Return on assets
Cash flow
Free cash flow was −$123M in fiscal 2025, — of revenue. Cash from operations minus capital spending.
FY21
Free cash flow −$75.2M
FY22
Free cash flow −$182M
FY23
Free cash flow $10.7M
FY24
Free cash flow −$168M
FY25
Free cash flow −$123M
Q3 '23
Free cash flow −$5.5M
Q4 '23
Free cash flow $13.2M
Q1 '24
Free cash flow −$0.6M
Q2 '24
Free cash flow −$66.7M
Q3 '24
Free cash flow −$41.6M
Q4 '24
Free cash flow −$59.0M
Q1 '25
Free cash flow −$39.8M
Q2 '25
Free cash flow −$25.3M
Q3 '25
Free cash flow −$30.4M
Q4 '25
Free cash flow −$28.0M
Q1 '26
Free cash flow —
Q2 '26
Free cash flow —
FY21
Cash from operations −$74.8M
Capital spending $0.4M
FY22
Cash from operations −$180M
Capital spending $2.5M
FY23
Cash from operations $11.9M
Capital spending $1.2M
FY24
Cash from operations −$168M
Capital spending $0.2M
FY25
Cash from operations −$123M
Capital spending $0.1M
Cash from operations
Capital spending
Q3 '23
Cash from operations −$5.2M
Capital spending $0.4M
Q4 '23
Cash from operations $13.6M
Capital spending $0.4M
Q1 '24
Cash from operations −$0.5M
Capital spending $0.1M
Q2 '24
Cash from operations −$66.6M
Capital spending $0.1M
Q3 '24
Cash from operations −$41.6M
Capital spending −$0.0M
Q4 '24
Cash from operations −$59.0M
Capital spending $0.0M
Q1 '25
Cash from operations −$39.8M
Capital spending $0.0M
Q2 '25
Cash from operations −$25.2M
Capital spending $0.0M
Q3 '25
Cash from operations −$30.4M
Capital spending $0.0M
Q4 '25
Cash from operations −$27.9M
Capital spending $0.1M
Q1 '26
Cash from operations −$36.9M
Capital spending —
Q2 '26
Cash from operations −$31.4M
Capital spending —
Cash from operations
Capital spending
Dividends, buybacks and share count
Amylyx Pharmaceuticals, Inc. returned — to shareholders in fiscal 2025. The diluted share count rose 38.8%.
FY21
Dividends —
Buybacks —
FY22
Dividends —
Buybacks —
FY23
Dividends —
Buybacks —
FY24
Dividends —
Buybacks —
FY25
Dividends —
Buybacks —
Dividends
Buybacks
FY21
Diluted shares 0.01B
FY22
Diluted shares 0.06B
FY23
Diluted shares 0.07B
FY24
Diluted shares 0.07B
FY25
Diluted shares 0.09B
Balance sheet
Cash, debt and the ratios that show how comfortably Amylyx Pharmaceuticals, Inc. can carry it.
FY21
Cash $96.1M
Debt —
FY22
Cash $347M
Debt —
FY23
Cash $371M
Debt —
FY24
Cash $177M
Debt —
FY25
Cash $317M
Debt —
Cash
Debt
| Fiscal year end | FY21 | FY22 | FY23 | FY24 | FY25 |
|---|---|---|---|---|---|
| Cash and short-term investments | $96.1M | $347M | $371M | $177M | $317M |
| Current ratio | 6.0x | 8.2x | 5.7x | 6.7x | 14.3x |
| Quick ratio | 6.0x | 8.0x | 5.2x | 6.7x | 14.3x |
| Total assets | $106M | $391M | $517M | $194M | $333M |
| Total liabilities | $17.4M | $50.8M | $84.0M | $28.9M | $27.4M |
| Shareholders' equity | −$151M | $341M | $433M | $165M | $305M |
| Net debt (− = net cash) | — | — | — | — | — |
Insider trades
Open-market purchases and sales by officers, directors and 10% owners, from Form 4 filings. 'Plan' marks trades under a pre-arranged Rule 10b5-1 plan.
Bought, 12 months
$0.0M
0 insiders
Sold, 12 months
$0.0M
0 insiders
Of sales under plans
—
$0.0M
No open-market insider trades in the last 12 months.
Piotroski F-score
Nine pass/fail tests of profitability, funding and efficiency. 8–9 is strong, 0–2 weak.
| Test | FY21 | FY22 | FY23 | FY24 | FY25 |
|---|---|---|---|---|---|
| Net income is positive | ✕ | ✕ | ✓ | ✕ | ✕ |
| Cash from operations is positive | ✕ | ✕ | ✓ | ✕ | ✕ |
| Return on assets rose | — | ✓ | ✓ | ✕ | ✓ |
| Cash from operations exceeds net income | ✓ | ✓ | ✕ | ✓ | ✓ |
| Debt fell relative to assets | — | — | — | — | — |
| Current ratio rose | — | ✓ | ✕ | ✓ | ✓ |
| Share count didn't rise | — | ✕ | ✕ | ✓ | ✕ |
| Gross margin rose | — | — | ✓ | ✕ | — |
| Revenue rose relative to assets | — | ✓ | ✓ | ✕ | ✕ |
| F-score | — / 3 | 4 / 7 | 5 / 8 | 3 / 8 | 3 / 7 |
| Accruals ratio | −12.4% | −7.4% | 8.2% | −37.7% | −8.1% |
| Altman Z'' | −13.74 | 6.25 | 8.85 | −9.69 | 7.18 |
5 years of figures
US$ millions unless stated. Hover a ratio's name for its definition.
| Fiscal year | FY21 | FY22 | FY23 | FY24 | FY25 |
|---|---|---|---|---|---|
| Income statement | |||||
| Revenue | $0.3M | $22.2M | $381M | $87.4M | $0.0M |
| Gross profit | — | $19.2M | $355M | $81.4M | $0.0M |
| Research and development | $44.0M | $93.5M | $128M | $104M | $90.4M |
| Operating income | −$82.7M | −$201M | $38.8M | −$315M | −$153M |
| Pretax income | −$87.9M | −$198M | $54.3M | −$302M | −$145M |
| Income tax | — | $0.8M | $5.0M | −$0.4M | $0.0M |
| Net income | −$87.9M | −$198M | $49.3M | −$302M | −$145M |
| Diluted EPS | −$13.35 | −$3.39 | $0.70 | −$4.43 | −$1.53 |
| Diluted shares | 0.01B | 0.06B | 0.07B | 0.07B | 0.09B |
| Cash flow | |||||
| Cash from operations | −$74.8M | −$180M | $11.9M | −$168M | −$123M |
| Capital expenditure | $0.4M | $2.5M | $1.2M | $0.2M | $0.1M |
| Free cash flow | −$75.2M | −$182M | $10.7M | −$168M | −$123M |
| Depreciation and amortization | $0.1M | $0.5M | $1.1M | $0.9M | $0.5M |
| Stock-based compensation | $3.1M | $21.7M | $37.2M | $33.0M | $27.6M |
| Balance sheet | |||||
| Cash and short-term investments | $96.1M | $347M | $371M | $177M | $317M |
| Current assets | $105M | $382M | $465M | $189M | $324M |
| Current liabilities | $17.4M | $46.6M | $82.0M | $28.4M | $22.7M |
| Inventory | — | $9.8M | $38.3M | — | — |
| Property and equipment, net | $0.5M | $2.6M | $2.7M | $1.0M | $0.3M |
| Total assets | $106M | $391M | $517M | $194M | $333M |
| Total liabilities | $17.4M | $50.8M | $84.0M | $28.9M | $27.4M |
| Shareholders' equity | −$151M | $341M | $433M | $165M | $305M |
| Margins | |||||
| Gross margin | — | 86.5% | 93.3% | 93.2% | — |
| Operating margin | −29,013.3% | −905.7% | 10.2% | −360.2% | — |
| EBITDA margin | −28,995.1% | −903.5% | 10.5% | −359.2% | — |
| Net margin | −30,853.0% | −892.4% | 12.9% | −345.4% | — |
| FCF margin | −26,369.1% | −820.5% | 2.8% | −192.1% | — |
| Returns | |||||
| Return on capital employed | −93.7% | −58.4% | 8.9% | −190.5% | −49.5% |
| Return on equity | — | −209.4% | 12.7% | −100.9% | −61.6% |
| Return on assets | −83.3% | −79.8% | 10.8% | −84.9% | −55.0% |
| Return on tangible equity | — | −58.2% | 11.4% | −183.1% | −47.4% |
| Growth | |||||
| Revenue growth | — | 7,700.0% | 1,612.9% | −77.1% | −100.0% |
| Net income growth | — | — | — | −712.4% | — |
| EPS growth | — | — | — | −732.9% | — |
| FCF growth | — | — | — | −1,671.5% | — |
| Share count change | — | 788.1% | 19.7% | −2.6% | 38.8% |
| Financial health | |||||
| Current ratio | 6.0x | 8.2x | 5.7x | 6.7x | 14.3x |
| Quick ratio | 6.0x | 8.0x | 5.2x | 6.7x | 14.3x |
| Capital allocation | |||||
| Capex / revenue | 123.9% | 11.4% | 0.3% | 0.2% | — |
| Stock comp / revenue | 1,100.4% | 97.7% | 9.8% | 37.8% | — |
| Quality scores | |||||
| Piotroski F-score | — | 4.0 | 5.0 | 3.0 | 3.0 |
| Altman Z'' | −13.7 | 6.3 | 8.8 | −9.7 | 7.2 |
| Accruals ratio | −12.4% | −7.4% | 8.2% | −37.7% | −8.1% |
Source: SEC EDGAR XBRL filings (CIK 0001658551). Data updated October 24, 2026. Quarterly fourth quarters are the full year minus the first nine months. For information only — not investment advice. Check the original filings before relying on any figure.