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Septerna, Inc.

SEPN Nasdaq Pharmaceutical Preparations Financials FY2023–FY2025

Revenue Total sales reported in the income statement.
$46.0M
4,174.5% vs prior year
Operating margin Operating income as a share of revenue.
−148.6%
7,369.8 pts
Net income Profit after all expenses, interest and tax.
−$48.9M
Free cash flow Cash from operations minus capital spending.
$110M
Return on capital After-tax operating income as a share of the money invested in the business: debt plus equity, minus cash.
—
Market cap Last close times the latest diluted share count, so it is approximate.
—
P/E Last close divided by diluted earnings per share over the last four quarters.
—
On −$0.53 EPS (TTM)

What Septerna, Inc. does

No business description yet.

Legal name
Septerna, Inc.
Fiscal year ends
December 31, 2025
Latest annual report
10-K · Mar 9, 2026
Accession · CIK
0001193125-26-098507
0001984086

Revenue and margins

Septerna, Inc. had $46.0M of revenue in fiscal 2025, up 4,174.5% on the year before.

Revenue
Revenue
Margins, % of revenue
Gross Operating Net FCF
Margins, % of revenue
Gross Operating Net FCF

Net income and earnings per share

Loss periods are shown in red.

Net income
Net income
Diluted EPS
Diluted EPS

Returns on capital

After-tax operating income as a share of the money invested in the business: debt plus equity, minus cash.

Return on capital, equity and assets (annual)
Return on capital Return on equity Return on assets

Cash flow

Free cash flow was $110M in fiscal 2025, 238.7% of revenue. Cash from operations minus capital spending.

Free cash flow
Free cash flow
Cash from operations vs capital spending
Cash from operations Capital spending
Cash from operations vs capital spending
Cash from operations Capital spending

Dividends, buybacks and share count

Septerna, Inc. returned — to shareholders in fiscal 2025. The diluted share count rose 347.5%.

Dividends and buybacks
Dividends Buybacks
Diluted shares outstanding (annual)

Balance sheet

Cash, debt and the ratios that show how comfortably Septerna, Inc. can carry it.

Cash vs debt (incl. leases)
Cash Debt
Fiscal year endFY23FY24FY25
Cash and short-term investments $88.5M$351M$391M
Current ratio 16.3x27.8x4.7x
Quick ratio 16.3x27.8x4.7x
Total assets $131M$457M$596M
Total liabilities $20.0M$36.5M$214M
Shareholders' equity −$38.4M$420M$382M
Net debt (− = net cash) ———

Insider trades

Open-market purchases and sales by officers, directors and 10% owners, from Form 4 filings. 'Plan' marks trades under a pre-arranged Rule 10b5-1 plan.

Bought, 12 months

$0.0M

0 insiders

Sold, 12 months

$0.0M

0 insiders

Of sales under plans

—

$0.0M

No open-market insider trades in the last 12 months.

Piotroski F-score

Nine pass/fail tests of profitability, funding and efficiency. 8–9 is strong, 0–2 weak.

TestFY23FY24FY25
Net income is positive ✓ ✕ ✕
Cash from operations is positive ✕ ✕ ✓
Return on assets rose — ✕ ✓
Cash from operations exceeds net income ✕ ✓ ✓
Debt fell relative to assets — — —
Current ratio rose — ✓ ✕
Share count didn't rise — ✕ ✕
Gross margin rose — — —
Revenue rose relative to assets — ✓ ✓
F-score — / 33 / 74 / 7
Accruals ratio 32.8%−1.5%−30.2%
Altman Z'' 2.2414.993.75

3 years of figures

US$ millions unless stated. Hover a ratio's name for its definition.

Download CSV
Fiscal yearFY23FY24FY25
Income statement
Revenue $0.2M $1.1M $46.0M
Research and development $36.0M $65.3M $97.6M
Operating income $2.1M −$80.8M −$68.3M
Pretax income −$48.9M −$72.3M −$48.9M
Income tax $0.7M −$0.5M $0.0M
Net income $4.2M −$71.8M −$48.9M
Net income to common $0.6M −$71.8M —
Diluted EPS $0.29 −$7.26 −$1.10
Diluted shares 0.00B 0.01B 0.04B
Cash flow
Cash from operations −$38.7M −$67.5M $110M
Capital expenditure $2.9M $2.1M $0.5M
Free cash flow −$41.6M −$69.6M $110M
Depreciation and amortization $0.8M $1.4M $1.6M
Stock-based compensation $1.6M $3.2M $8.5M
Balance sheet
Cash and short-term investments $88.5M $351M $391M
Current assets $113M $357M $411M
Current liabilities $6.9M $12.8M $86.9M
Property and equipment, net $4.7M $5.1M $4.4M
Total assets $131M $457M $596M
Total liabilities $20.0M $36.5M $214M
Shareholders' equity −$38.4M $420M $382M
Margins
Operating margin 1,374.2% −7,518.4% −148.6%
EBITDA margin 1,904.0% −7,388.2% −145.1%
Net margin 2,768.2% −6,678.9% −106.4%
FCF margin −27,550.3% −6,471.9% 238.7%
Returns
Return on capital employed 1.7% −18.2% −13.4%
Return on equity — −37.6% −12.2%
Return on assets 3.2% −24.4% −9.3%
Return on tangible equity — −17.1% −12.8%
Growth
Revenue growth — 611.9% 4,174.5%
Net income growth — −1,817.7% —
EPS growth — −2,603.4% —
Share count change — 354.3% 347.5%
Financial health
Current ratio 16.3x 27.8x 4.7x
Quick ratio 16.3x 27.8x 4.7x
Capital allocation
Capex / revenue 1,906.0% 195.6% 1.1%
Stock comp / revenue 1,072.8% 293.2% 18.4%
Quality scores
Piotroski F-score — 3.0 4.0
Altman Z'' 2.2 15.0 3.8
Accruals ratio 32.8% −1.5% −30.2%

Source: SEC EDGAR XBRL filings (CIK 0001984086). Data updated October 24, 2026. Quarterly fourth quarters are the full year minus the first nine months. For information only — not investment advice. Check the original filings before relying on any figure.

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