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Amylyx Pharmaceuticals, Inc.

AMLX Nasdaq Pharmaceutical Preparations Financials FY2021–FY2025

Amylyx Pharmaceuticals, Inc. had $0.0M of revenue in fiscal 2025, down 100.0% on the year before.

Download report 3-page PDF: the company, its results and charts with peers.

Last close Β· Oct 23, 2026

$27.20

4.8%

What Amylyx Pharmaceuticals, Inc. does

AMLX Β· Pharmaceutical Preparations

From its latest annual report

No business description yet.

Filing details

Legal name
Amylyx Pharmaceuticals, Inc.
Fiscal year ends
December 31, 2025
Latest annual report
10-K Β· Mar 3, 2026
Accession Β· CIK
0001193125-26-086645 Β· 0001658551
Charts by

KIRA’s summary AI analyst

Hi! I read Amylyx Pharmaceuticals, Inc.’s latest annual report (fiscal 2025). Here is what stands out:

4 to watch

Amylyx Pharmaceuticals, Inc. in 30 seconds

Good So-so Weak

Weak

Are sales growing?

βˆ’100.0%

No. Sales fell 100.0% last year.

Weak

Does it make a profit?

βˆ’$145M

No. It lost money last year.

Weak

How healthy are the accounts?

3 / 7

Weak. It passes 3 of 7 health tests.

For information

How is the share priced?

β€”

No P/E: it made no profit over the last four quarters.

Rules of thumb on reported numbers. A starting point, not a recommendation.

Key numbers, fiscal 2025

Market cap Last close times the latest diluted share count, so it is approximate.
$3.0B
Oct 23 close
P/E Last close divided by diluted earnings per share over the last four quarters.
β€”
On βˆ’$1.41 EPS (TTM)

Revenue

Total sales reported in the income statement.

KIRA Β· Amylyx Pharmaceuticals, Inc. had $0.0M of revenue in fiscal 2025, down 100.0% on the year before.

See the full section β†’

Operating margin

Operating income as a share of revenue.

See the full section β†’

Net income

Profit after all expenses, interest and tax.

KIRA Β· Amylyx Pharmaceuticals, Inc. lost $145M in fiscal 2025.

See the full section β†’

Free cash flow

Cash from operations minus capital spending.

KIRA Β· Free cash flow was βˆ’$123M in fiscal 2025, β€” of revenue.

See the full section β†’

Return on capital

After-tax operating income as a share of the money invested in the business: debt plus equity, minus cash.

See the full section β†’

Sales and profit

Is it selling more, and how much does it keep?

Results dates

In plain words: Every quarter, companies publish how much they sold and earned. These are the days Amylyx Pharmaceuticals, Inc. did it, and the next one. Share prices often move a lot on those days.

Next results

November 5, 2026

Thursday Β· in 11 days

Time
Time not announced
Covers
Period ended Sep 30, 2026
Expected EPS
βˆ’$0.38
Source
Earnings calendar
See who else reports that week β†’
Date Results for Time Source
Aug 6, 2026 Q2 '26 Before the market opens 8-K β†—
May 7, 2026 Q1 '26 Before the market opens 8-K β†—
Mar 3, 2026 Q4 '25 Before the market opens 8-K β†—
Nov 6, 2025 Q3 '25 Before the market opens 8-K β†—
Aug 7, 2025 Q2 '25 Before the market opens 8-K β†—
May 8, 2025 Q1 '25 Before the market opens 8-K β†—
Mar 4, 2025 Q4 '24 Before the market opens 8-K β†—
Nov 7, 2024 Q3 '24 Before the market opens 8-K β†—

From SEC filings: the results press release (8-K) or, without one, the quarterly or annual report.

Revenue and margins

KIRA Β· Amylyx Pharmaceuticals, Inc. had $0.0M of revenue in fiscal 2025, down 100.0% on the year before.

In plain words: Revenue is all the money customers paid. The margins show how many cents of each dollar of sales are left over at each step: after making the product (gross), after running the business (operating) and after everything, tax included (net).

Revenue
Revenue
Margins, % of revenue
Gross Operating Net FCF
Margins, % of revenue
Gross Operating Net FCF

Net income and earnings per share

KIRA Β· Amylyx Pharmaceuticals, Inc. lost $145M in fiscal 2025.

Loss periods are shown in red.

In plain words: Net income is the profit left after every cost and tax. Earnings per share (EPS) splits that profit across every share, so it shows what one share earned.

Net income
Net income
Diluted EPS
Diluted EPS

Cash and shareholders

How much cash comes in, and where does it go?

Cash flow

KIRA Β· Free cash flow was βˆ’$123M in fiscal 2025, β€” of revenue.

Cash from operations minus capital spending.

In plain words: Profit on paper is not the same as cash in the bank. Free cash flow is the cash left after paying to run and maintain the business: the money it can hand back to shareholders, save or invest.

Free cash flow
Free cash flow
Cash from operations vs capital spending
Cash from operations Capital spending
Cash from operations vs capital spending
Cash from operations Capital spending

Dividends, buybacks and share count

In plain words: Companies hand cash back in two ways: dividends (cash paid to shareholders) and buybacks (buying back their own shares, so each remaining share owns a bigger slice).

Dividends and buybacks
Dividends Buybacks
Diluted shares outstanding (annual)

Insider trades

KIRA Β· No open-market insider trades in the last 12 months.

Open-market purchases and sales by officers, directors and 10% owners, from Form 4 filings. β€œPlan” marks trades under a pre-arranged Rule 10b5-1 plan.

In plain words: Insiders are the people who run or own a big part of the company. Buying with their own money can signal confidence; selling often has personal reasons, like taxes or diversifying.

Bought, 12 months

$0.0M

0 insiders

Sold, 12 months

$0.0M

0 insiders

Of sales under plans

β€”

$0.0M

No open-market insider trades in the last 12 months.

Financial health

Can it carry its debts, and how well does it use its money?

Balance sheet

Cash, debt and the ratios that show how comfortably Amylyx Pharmaceuticals, Inc. can carry it.

In plain words: What the company owns and what it owes. More cash than debt is a cushion for bad times; a lot of debt leaves less room when business slows down.

Cash vs debt (incl. leases)
Cash Debt
Fiscal year endFY21FY22FY23FY24FY25
Cash and short-term investments $96.1M$347M$371M$177M$317M
Current ratio 6.0x8.2x5.7x6.7x14.3x
Quick ratio 6.0x8.0x5.2x6.7x14.3x
Total assets $106M$391M$517M$194M$333M
Total liabilities $17.4M$50.8M$84.0M$28.9M$27.4M
Shareholders' equity βˆ’$151M$341M$433M$165M$305M
Net debt (βˆ’ = net cash) β€”β€”β€”β€”β€”

Returns on capital

After-tax operating income as a share of the money invested in the business: debt plus equity, minus cash.

In plain words: How much profit the business makes on the money put into it. A higher percentage means each dollar invested works harder.

Return on capital, equity and assets (annual)
Return on capital Return on equity Return on assets

Piotroski F-score

KIRA Β· Amylyx Pharmaceuticals, Inc. passes 3 of 7 financial health tests (Piotroski F-score).

Nine pass/fail tests of profitability, funding and efficiency. 8–9 is strong, 0–2 weak.

In plain words: Nine yes/no tests of financial health, one point each. A green tick is a pass: 7 to 9 points is solid, 0 to 3 is weak.

TestFY21FY22FY23FY24FY25
Net income is positive βœ• βœ• βœ“ βœ• βœ•
Cash from operations is positive βœ• βœ• βœ“ βœ• βœ•
Return on assets rose β€” βœ“ βœ“ βœ• βœ“
Cash from operations exceeds net income βœ“ βœ“ βœ• βœ“ βœ“
Debt fell relative to assets β€” β€” β€” β€” β€”
Current ratio rose β€” βœ“ βœ• βœ“ βœ“
Share count didn't rise β€” βœ• βœ• βœ“ βœ•
Gross margin rose β€” β€” βœ“ βœ• β€”
Revenue rose relative to assets β€” βœ“ βœ“ βœ• βœ•
F-score β€” / 34 / 75 / 83 / 83 / 7
Accruals ratio βˆ’12.4%βˆ’7.4%8.2%βˆ’37.7%βˆ’8.1%
Altman Z'' βˆ’13.746.258.85βˆ’9.697.18

All figures

Every number, year by year.

5 years of figures

Amounts in USD. Hover a ratio’s name for its definition.

In plain words: Every number we have, year by year. Download it as a spreadsheet if you want to dig deeper.

Download CSV
Fiscal yearFY21FY22FY23FY24FY25
Income statement
Revenue $0.3M $22.2M $381M $87.4M $0.0M
Gross profit β€” $19.2M $355M $81.4M $0.0M
Research and development $44.0M $93.5M $128M $104M $90.4M
Operating income βˆ’$82.7M βˆ’$201M $38.8M βˆ’$315M βˆ’$153M
Pretax income βˆ’$87.9M βˆ’$198M $54.3M βˆ’$302M βˆ’$145M
Income tax β€” $0.8M $5.0M βˆ’$0.4M $0.0M
Net income βˆ’$87.9M βˆ’$198M $49.3M βˆ’$302M βˆ’$145M
Diluted EPS βˆ’$13.35 βˆ’$3.39 $0.70 βˆ’$4.43 βˆ’$1.53
Diluted shares 0.01B 0.06B 0.07B 0.07B 0.09B
Cash flow
Cash from operations βˆ’$74.8M βˆ’$180M $11.9M βˆ’$168M βˆ’$123M
Capital expenditure $0.4M $2.5M $1.2M $0.2M $0.1M
Free cash flow βˆ’$75.2M βˆ’$182M $10.7M βˆ’$168M βˆ’$123M
Depreciation and amortization $0.1M $0.5M $1.1M $0.9M $0.5M
Stock-based compensation $3.1M $21.7M $37.2M $33.0M $27.6M
Balance sheet
Cash and short-term investments $96.1M $347M $371M $177M $317M
Current assets $105M $382M $465M $189M $324M
Current liabilities $17.4M $46.6M $82.0M $28.4M $22.7M
Inventory β€” $9.8M $38.3M β€” β€”
Property and equipment, net $0.5M $2.6M $2.7M $1.0M $0.3M
Total assets $106M $391M $517M $194M $333M
Total liabilities $17.4M $50.8M $84.0M $28.9M $27.4M
Shareholders' equity βˆ’$151M $341M $433M $165M $305M
Margins
Gross margin β€” 86.5% 93.3% 93.2% β€”
Operating margin βˆ’29,013.3% βˆ’905.7% 10.2% βˆ’360.2% β€”
EBITDA margin βˆ’28,995.1% βˆ’903.5% 10.5% βˆ’359.2% β€”
Net margin βˆ’30,853.0% βˆ’892.4% 12.9% βˆ’345.4% β€”
FCF margin βˆ’26,369.1% βˆ’820.5% 2.8% βˆ’192.1% β€”
Returns
Return on capital employed βˆ’93.7% βˆ’58.4% 8.9% βˆ’190.5% βˆ’49.5%
Return on equity β€” βˆ’209.4% 12.7% βˆ’100.9% βˆ’61.6%
Return on assets βˆ’83.3% βˆ’79.8% 10.8% βˆ’84.9% βˆ’55.0%
Return on tangible equity β€” βˆ’58.2% 11.4% βˆ’183.1% βˆ’47.4%
Growth
Revenue growth β€” 7,700.0% 1,612.9% βˆ’77.1% βˆ’100.0%
Net income growth β€” β€” β€” βˆ’712.4% β€”
EPS growth β€” β€” β€” βˆ’732.9% β€”
FCF growth β€” β€” β€” βˆ’1,671.5% β€”
Share count change β€” 788.1% 19.7% βˆ’2.6% 38.8%
Financial health
Current ratio 6.0x 8.2x 5.7x 6.7x 14.3x
Quick ratio 6.0x 8.0x 5.2x 6.7x 14.3x
Capital allocation
Capex / revenue 123.9% 11.4% 0.3% 0.2% β€”
Stock comp / revenue 1,100.4% 97.7% 9.8% 37.8% β€”
Quality scores
Piotroski F-score β€” 4.0 5.0 3.0 3.0
Altman Z'' βˆ’13.7 6.3 8.8 βˆ’9.7 7.2
Accruals ratio βˆ’12.4% βˆ’7.4% 8.2% βˆ’37.7% βˆ’8.1%

Source: SEC EDGAR XBRL filings (CIK 0001658551). Data updated October 24, 2026. Quarterly fourth quarters are the full year minus the first nine months. For information only β€” not investment advice. Check the original filings before relying on any figure.

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