SNDX Nasdaq Pharmaceutical Preparations Financials FY2016βFY2025
Syndax Pharmaceuticals Inc had $172M of revenue in fiscal 2025, up 627.8% on the year before. Over five years, revenue changed +157.7% a year on average.
Last close Β· Oct 23, 2026
$13.40
1.3%Hi! I read Syndax Pharmaceuticals Incβs latest annual report (fiscal 2025). Here is what stands out:
Good So-so Weak
Are sales growing?
+627.8%
Yes. Sales grew 627.8% last year.
Does it make a profit?
β165.6%
No. It lost money last year.
Does profit turn into cash?
β187.5%
No. It spent more cash than it brought in.
How healthy are the accounts?
1 / 8
Weak. It passes 1 of 8 health tests.
How is the share priced?
β
No P/E: it made no profit over the last four quarters.
Rules of thumb on reported numbers. A starting point, not a recommendation.
Is it selling more, and how much does it keep?
KIRA Β· Syndax Pharmaceuticals Inc had $172M of revenue in fiscal 2025, up 627.8% on the year before. Over five years, revenue changed +157.7% a year on average. Its operating margin was β158.4%, up 1,276.0Β pts: of every 100 in sales, about β158 is left after running the business.
In plain words: Revenue is all the money customers paid. The margins show how many cents of each dollar of sales are left over at each step: after making the product (gross), after running the business (operating) and after everything, tax included (net).
Revenue
Revenue
Margins, % of revenue
Margins, % of revenue
KIRA Β· Syndax Pharmaceuticals Inc lost $285M in fiscal 2025.
Loss periods are shown in red.
In plain words: Net income is the profit left after every cost and tax. Earnings per share (EPS) splits that profit across every share, so it shows what one share earned.
Net income
Net income
Diluted EPS
Diluted EPS
How much cash comes in, and where does it go?
KIRA Β· Free cash flow was β$323M in fiscal 2025, β187.5% of revenue.
Cash from operations minus capital spending.
In plain words: Profit on paper is not the same as cash in the bank. Free cash flow is the cash left after paying to run and maintain the business: the money it can hand back to shareholders, save or invest.
Free cash flow
Cash from operations vs capital spending
Cash from operations vs capital spending
In plain words: Companies hand cash back in two ways: dividends (cash paid to shareholders) and buybacks (buying back their own shares, so each remaining share owns a bigger slice).
Dividends and buybacks
Diluted shares outstanding (annual)
KIRA Β· In the last 12 months, insiders sold $2.7M of shares on the open market and bought none.
Open-market purchases and sales by officers, directors and 10% owners, from Form 4 filings. βPlanβ marks trades under a pre-arranged Rule 10b5-1 plan.
In plain words: Insiders are the people who run or own a big part of the company. Buying with their own money can signal confidence; selling often has personal reasons, like taxes or diversifying.
Bought, 12 months
$0.0M
0 insiders
Sold, 12 months
$2.7M
3 insiders
Of sales under plans
72%
$2.0M
| Date | Insider | Trade | Shares | Price | Value | Filing |
|---|---|---|---|---|---|---|
| Jul 8, 2026 | Michael A MetzgerChief Executive Officer, Director | Sold plan | 32,375 | $24.24 | $0.8M | Form 4 |
| Jun 12, 2026 | Nicholas A.J. BotwoodHead of R&D, CMO | Sold plan | 31,235 | $18.14 | $0.6M | Form 4 |
| Jun 11, 2026 | Nicholas A.J. BotwoodHead of R&D, CMO | Sold plan | 34,280 | $18.00 | $0.6M | Form 4 |
| Jun 1, 2026 | Keith A. GoldanChief Financial Officer | Sold | 1,177 | $18.99 | $0.0M | Form 4 |
| Jun 1, 2026 | Michael A MetzgerChief Executive Officer, Director | Sold | 6,847 | $18.99 | $0.1M | Form 4 |
| Feb 9, 2026 | Keith A. GoldanChief Financial Officer | Sold | 3,410 | $21.03 | $0.1M | Form 4 |
| Feb 9, 2026 | Michael A MetzgerChief Executive Officer, Director | Sold | 17,159 | $21.03 | $0.4M | Form 4 |
| Feb 6, 2026 | Keith A. GoldanChief Financial Officer | Sold | 2,082 | $20.62 | $0.0M | Form 4 |
| Feb 6, 2026 | Michael A MetzgerChief Executive Officer, Director | Sold | 7,412 | $20.62 | $0.2M | Form 4 |
Can it carry its debts, and how well does it use its money?
KIRA Β· Syndax Pharmaceuticals Inc owes $300M more than it holds in cash.
Cash, debt and the ratios that show how comfortably Syndax Pharmaceuticals Inc can carry it.
In plain words: What the company owns and what it owes. More cash than debt is a cushion for bad times; a lot of debt leaves less room when business slows down.
Cash vs debt (incl. leases)
| Fiscal year end | FY21 | FY22 | FY23 | FY24 | FY25 |
|---|---|---|---|---|---|
| Cash and short-term investments | $440M | $476M | $571M | $573M | $394M |
| Debt incl. finance leases | β | β | $0.0M | $682M | $694M |
| Debt / equity | β | β | 0.0x | 2.4x | 10.7x |
| Interest coverage | 13.8x | β48.4x | β1,105.5x | β | β45,514.0x |
| Current ratio | 21.7x | 16.9x | 10.0x | 5.8x | 4.4x |
| Quick ratio | 21.7x | 16.9x | 10.0x | 5.8x | 4.1x |
| Total assets | $450M | $497M | $613M | $725M | $530M |
| Total liabilities | $41.3M | $29.8M | $58.7M | $437M | $465M |
| Shareholders' equity | $408M | $467M | $554M | $288M | $64.6M |
| Net debt (β = net cash) | β | β | β$571M | $109M | $300M |
KIRA Β· Its return on capital was β59.2%: every 100 invested in the business earned about β59 in a year.
After-tax operating income as a share of the money invested in the business: debt plus equity, minus cash.
In plain words: How much profit the business makes on the money put into it. A higher percentage means each dollar invested works harder.
Return on capital, equity and assets (annual)
KIRA Β· Syndax Pharmaceuticals Inc passes 1 of 8 financial health tests (Piotroski F-score).
Nine pass/fail tests of profitability, funding and efficiency. 8β9 is strong, 0β2 weak.
In plain words: Nine yes/no tests of financial health, one point each. A green tick is a pass: 7 to 9 points is solid, 0 to 3 is weak.
| Test | FY16 | FY17 | FY18 | FY19 | FY20 | FY21 | FY22 | FY23 | FY24 | FY25 |
|---|---|---|---|---|---|---|---|---|---|---|
| Net income is positive | β | β | β | β | β | β | β | β | β | β |
| Cash from operations is positive | β | β | β | β | β | β | β | β | β | β |
| Return on assets rose | β | β | β | β | β | β | β | β | β | β |
| Cash from operations exceeds net income | β | β | β | β | β | β | β | β | β | β |
| Debt fell relative to assets | β | β | β | β | β | β | β | β | β | β |
| Current ratio rose | β | β | β | β | β | β | β | β | β | β |
| Share count didn't rise | β | β | β | β | β | β | β | β | β | β |
| Gross margin rose | β | β | β | β | β | β | β | β | β | β |
| Revenue rose relative to assets | β | β | β | β | β | β | β | β | β | β |
| F-score | β / 3 | 2 / 7 | 2 / 7 | 2 / 7 | 3 / 7 | 6 / 7 | 1 / 7 | 1 / 7 | 2 / 8 | 1 / 8 |
| Accruals ratio | β8.5% | β10.9% | β4.9% | β7.4% | β1.0% | β1.1% | β3.3% | β8.8% | β6.6% | 6.0% |
| Altman Z'' | β2.37 | β2.78 | β16.08 | β25.93 | 3.82 | 13.07 | 15.96 | 8.19 | β3.43 | β7.54 |
Every number, year by year.
Amounts in USD. Hover a ratioβs name for its definition.
In plain words: Every number we have, year by year. Download it as a spreadsheet if you want to dig deeper.
| Fiscal year | FY16 | FY17 | FY18 | FY19 | FY20 | FY21 | FY22 | FY23 | FY24 | FY25 |
|---|---|---|---|---|---|---|---|---|---|---|
| Income statement | ||||||||||
| Revenue | $1.2M | $2.1M | $1.5M | $1.5M | $1.5M | $140M | $0.0M | $0.0M | $23.7M | $172M |
| Research and development | $31.7M | $48.2M | $60.1M | $43.0M | $50.4M | $88.2M | $118M | $163M | $242M | $259M |
| Operating income | β$43.8M | β$62.0M | β$75.9M | β$57.5M | β$71.4M | $26.2M | β$152M | β$230M | β$340M | β$273M |
| Interest expense | β | β | β | β | $2.4M | $1.9M | $3.1M | $0.2M | β$0.0M | $0.0M |
| Income tax | $0.0M | $0.0M | $0.0M | $0.0M | $0.0M | $0.0M | β | β | β | $0.4M |
| Net income | β$44.5M | β$60.8M | β$74.0M | β$56.0M | β$73.2M | $24.9M | β$149M | β$209M | β$319M | β$285M |
| Net income to common | β$47.1M | β$60.8M | β$74.0M | β$56.0M | β$77.1M | $24.9M | β$149M | β$209M | β$319M | β$285M |
| Diluted EPS | β$3.22 | β$2.90 | β$2.92 | β$1.84 | β$1.87 | $0.46 | β$2.46 | β$2.98 | β$3.72 | β$3.29 |
| Diluted shares | 0.01B | 0.02B | 0.03B | 0.03B | 0.04B | 0.05B | 0.06B | 0.07B | 0.09B | 0.09B |
| Cash flow | ||||||||||
| Cash from operations | β$35.2M | β$47.4M | β$68.5M | β$50.6M | β$71.3M | $29.1M | β$134M | β$161M | β$275M | β$323M |
| Capital expenditure | $0.3M | $0.1M | $0.2M | β | $0.0M | $0.1M | $0.0M | $0.0M | $0.0M | $0.2M |
| Free cash flow | β$35.4M | β$47.5M | β$68.7M | β | β$71.3M | $29.0M | β$134M | β$161M | β$275M | β$323M |
| Depreciation and amortization | $0.1M | $0.1M | $0.1M | $0.1M | $0.1M | $43.0M | $33.0M | $12.0M | $8.0M | $6.0M |
| Stock-based compensation | $4.7M | $5.5M | $6.2M | $6.0M | $9.1M | $13.3M | $16.0M | $31.0M | $43.0M | $47.5M |
| Balance sheet | ||||||||||
| Cash and short-term investments | $105M | $130M | $80.9M | $59.8M | $293M | $440M | $476M | $571M | $573M | $394M |
| Total debt | β | β | β | β | β | β | β | $0.0M | $682M | $694M |
| Current assets | $109M | $133M | $83.3M | $62.3M | $299M | $448M | $490M | $581M | $603M | $528M |
| Current liabilities | $10.4M | $15.8M | $16.1M | $18.4M | $18.9M | $20.7M | $29.1M | $58.1M | $104M | $120M |
| Inventory | β | β | β | β | β | β | β | $0.0M | $0.4M | $32.8M |
| Property and equipment, net | $0.3M | $0.3M | $0.4M | $0.3M | $0.2M | $0.3M | $0.0M | $0.0M | $0.0M | $0.2M |
| Total assets | $109M | $137M | $83.9M | $63.5M | $301M | $450M | $497M | $613M | $725M | $530M |
| Total liabilities | $24.9M | $32.9M | $30.9M | $31.9M | $48.4M | $41.3M | $29.8M | $58.7M | $437M | $465M |
| Preferred stock | $0.0M | β | β | β | β | $0.0M | $0.0M | $0.0M | $0.0M | $0.0M |
| Shareholders' equity | $84.1M | $104M | $53.0M | $31.6M | $252M | $408M | $467M | $554M | $288M | $64.6M |
| Margins | ||||||||||
| Operating margin | β3,587.4% | β2,939.0% | β5,001.7% | β3,792.9% | β4,708.2% | 18.8% | β | β | β1,434.4% | β158.4% |
| EBITDA margin | β3,580.1% | β2,935.4% | β4,996.6% | β3,786.9% | β4,702.2% | 49.5% | β | β | β1,400.6% | β155.0% |
| Net margin | β3,645.2% | β2,884.3% | β4,875.5% | β3,694.6% | β4,822.5% | 17.8% | β | β | β1,346.1% | β165.6% |
| FCF margin | β2,903.1% | β2,251.2% | β4,529.9% | β | β4,697.4% | 20.8% | β | β | β1,160.9% | β187.5% |
| Returns | ||||||||||
| Return on capital | β | β | β | β | β | β | β | β | β67.6% | β59.2% |
| Return on capital employed | β44.4% | β51.0% | β111.9% | β127.4% | β25.4% | 6.1% | β32.4% | β41.4% | β54.7% | β66.7% |
| Return on equity | β52.9% | β64.5% | β94.0% | β132.4% | β51.6% | 7.5% | β34.1% | β41.0% | β75.7% | β161.8% |
| Return on assets | β40.8% | β49.4% | β66.9% | β76.0% | β40.2% | 6.6% | β31.5% | β37.7% | β47.7% | β45.5% |
| Return on tangible equity | β55.9% | β58.3% | β139.4% | β177.4% | β30.6% | 6.1% | β31.9% | β37.8% | β110.6% | β441.6% |
| Growth | ||||||||||
| Revenue growth | β | 72.8% | β28.0% | 0.0% | 0.0% | 9,109.6% | β100.0% | β | β | 627.8% |
| Net income growth | β | β | β | β | β | β | β699.1% | β | β | β |
| EPS growth | β | β | β | β | β | β | β634.8% | β | β | β |
| FCF growth | β | β | β | β | β | β | β560.9% | β | β | β |
| Share count change | β | 43.6% | 20.8% | 20.2% | 35.5% | 29.8% | 13.3% | 15.8% | 21.7% | 1.2% |
| Financial health | ||||||||||
| Debt / equity | β | β | β | β | β | β | β | 0.0x | 2.4x | 10.7x |
| Interest coverage | β | β | β | β | β30.3x | 13.8x | β48.4x | β1,105.5x | β | β45,514.0x |
| Current ratio | 10.5x | 8.4x | 5.2x | 3.4x | 15.8x | 21.7x | 16.9x | 10.0x | 5.8x | 4.4x |
| Quick ratio | 10.5x | 8.4x | 5.2x | 3.4x | 15.8x | 21.7x | 16.9x | 10.0x | 5.8x | 4.1x |
| Capital allocation | ||||||||||
| Capex / revenue | 21.4% | 4.0% | 12.3% | β | 0.0% | 0.1% | β | β | 0.0% | 0.1% |
| Stock comp / revenue | 385.9% | 258.5% | 408.8% | 395.8% | 597.0% | 9.5% | β | β | 181.7% | 27.6% |
| Quality scores | ||||||||||
| Piotroski F-score | β | 2.0 | 2.0 | 2.0 | 3.0 | 6.0 | 1.0 | 1.0 | 2.0 | 1.0 |
| Altman Z'' | β2.4 | β2.8 | β16.1 | β25.9 | 3.8 | 13.1 | 16.0 | 8.2 | β3.4 | β7.5 |
| Accruals ratio | β8.5% | β10.9% | β4.9% | β7.4% | β1.0% | β1.1% | β3.3% | β8.8% | β6.6% | 6.0% |
Source: SEC EDGAR XBRL filings (CIK 0001395937). Data updated October 24, 2026. Quarterly fourth quarters are the full year minus the first nine months. For information only β not investment advice. Check the original filings before relying on any figure.
