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Castle Biosciences Inc

CSTL Nasdaq Services-Medical Laboratories Financials FY2018–FY2025

Castle Biosciences Inc had $344M of revenue in fiscal 2025, up 3.7% on the year before. Over five years, revenue changed +40.6% a year on average.

Download report 3-page PDF: the company, its results and charts with peers.

Last close Β· Oct 23, 2026

$33.08

0.3%

What Castle Biosciences Inc does

CSTL Β· Services-Medical Laboratories

From its latest annual report

No business description yet.

Filing details

Legal name
CASTLE BIOSCIENCES INC
Fiscal year ends
December 31, 2025
Latest annual report
10-K Β· Feb 26, 2026
Accession Β· CIK
0001628280-26-012272 Β· 0001447362

KIRA’s summary AI analyst

Hi! I read Castle Biosciences Inc’s latest annual report (fiscal 2025). Here is what stands out:

3 strengths 3 to watch

1.Sales and profit

See section β†’
  • Castle Biosciences Inc had $344M of revenue in fiscal 2025, up 3.7% on the year before. Over five years, revenue changed +40.6% a year on average.
  • Its operating margin was βˆ’12.4%, down 15.0Β pts: of every 100 in sales, about βˆ’12 is left after running the business.
  • Castle Biosciences Inc lost $24.2M in fiscal 2025.

3.Financial health

See section β†’
  • Castle Biosciences Inc has $289M more cash than debt.
  • Its return on capital was βˆ’18.6%: every 100 invested in the business earned about βˆ’19 in a year.
  • Castle Biosciences Inc passes 4 of 9 financial health tests (Piotroski F-score).

Castle Biosciences Inc in 30 seconds

Good So-so Weak

So-so

Are sales growing?

+3.7%

Only a little. Sales grew 3.7% last year.

Weak

Does it make a profit?

βˆ’7.0%

No. It lost money last year.

So-so

Does profit turn into cash?

8.2%

Partly. 8.2% of sales ends up as free cash.

So-so

How healthy are the accounts?

4 / 9

Mixed. It passes 4 of 9 health tests.

For information

How is the share priced?

β€”

No P/E: it made no profit over the last four quarters.

Rules of thumb on reported numbers. A starting point, not a recommendation.

Key numbers, fiscal 2025

Market cap Last close times the latest diluted share count, so it is approximate.
$1.0B
Oct 23 close
P/E Last close divided by diluted earnings per share over the last four quarters.
β€”
On βˆ’$0.64 EPS (TTM)

Revenue

Total sales reported in the income statement.

KIRA Β· Castle Biosciences Inc had $344M of revenue in fiscal 2025, up 3.7% on the year before. Over five years, revenue changed +40.6% a year on average.

See the full section β†’

Operating margin

Operating income as a share of revenue.

KIRA Β· Its operating margin was βˆ’12.4%, down 15.0Β pts: of every 100 in sales, about βˆ’12 is left after running the business.

See the full section β†’

Net income

Profit after all expenses, interest and tax.

KIRA Β· Castle Biosciences Inc lost $24.2M in fiscal 2025.

See the full section β†’

Free cash flow

Cash from operations minus capital spending.

KIRA Β· Free cash flow was $28.3M in fiscal 2025, 8.2% of revenue.

See the full section β†’

Return on capital

After-tax operating income as a share of the money invested in the business: debt plus equity, minus cash.

KIRA Β· Its return on capital was βˆ’18.6%: every 100 invested in the business earned about βˆ’19 in a year.

See the full section β†’

Sales and profit

Is it selling more, and how much does it keep?

Results dates

In plain words: Every quarter, companies publish how much they sold and earned. These are the days Castle Biosciences Inc did it, and the next one. Share prices often move a lot on those days.

Next results

November 5, 2026

Thursday Β· in 10 days

Time
After the market closes
Covers
Period ended Sep 30, 2026
Expected EPS
βˆ’$0.38
Source
Earnings calendar
See who else reports that week β†’
Date Results for Time Source
Jul 30, 2026 Q2 '26 After the market closes 8-K β†—
May 6, 2026 Q1 '26 After the market closes 8-K β†—
Jan 11, 2026 Q4 '25 Time not announced 8-K β†—
Nov 3, 2025 Q3 '25 After the market closes 8-K β†—
Aug 4, 2025 Q2 '25 After the market closes 8-K β†—
May 5, 2025 Q1 '25 After the market closes 8-K β†—
Jan 12, 2025 Q4 '24 Time not announced 8-K β†—
Nov 4, 2024 Q3 '24 After the market closes 8-K β†—

From SEC filings: the results press release (8-K) or, without one, the quarterly or annual report.

Revenue and margins

KIRA Β· Castle Biosciences Inc had $344M of revenue in fiscal 2025, up 3.7% on the year before. Over five years, revenue changed +40.6% a year on average. Its operating margin was βˆ’12.4%, down 15.0Β pts: of every 100 in sales, about βˆ’12 is left after running the business.

In plain words: Revenue is all the money customers paid. The margins show how many cents of each dollar of sales are left over at each step: after making the product (gross), after running the business (operating) and after everything, tax included (net).

Revenue

Revenue

Margins, % of revenue

Gross Operating Net FCF

Margins, % of revenue

Gross Operating Net FCF

Net income and earnings per share

KIRA Β· Castle Biosciences Inc lost $24.2M in fiscal 2025.

Loss periods are shown in red.

In plain words: Net income is the profit left after every cost and tax. Earnings per share (EPS) splits that profit across every share, so it shows what one share earned.

Net income

Net income

Diluted EPS

Diluted EPS

Cash and shareholders

How much cash comes in, and where does it go?

Cash flow

KIRA Β· Free cash flow was $28.3M in fiscal 2025, 8.2% of revenue.

Cash from operations minus capital spending.

In plain words: Profit on paper is not the same as cash in the bank. Free cash flow is the cash left after paying to run and maintain the business: the money it can hand back to shareholders, save or invest.

Free cash flow

Free cash flow

Cash from operations vs capital spending

Cash from operations Capital spending

Cash from operations vs capital spending

Cash from operations Capital spending

Dividends, buybacks and share count

In plain words: Companies hand cash back in two ways: dividends (cash paid to shareholders) and buybacks (buying back their own shares, so each remaining share owns a bigger slice).

Dividends and buybacks

Dividends Buybacks

Diluted shares outstanding (annual)

Insider trades

KIRA Β· No open-market insider trades in the last 12 months.

Open-market purchases and sales by officers, directors and 10% owners, from Form 4 filings. β€œPlan” marks trades under a pre-arranged Rule 10b5-1 plan.

In plain words: Insiders are the people who run or own a big part of the company. Buying with their own money can signal confidence; selling often has personal reasons, like taxes or diversifying.

Bought, 12 months

$0.0M

0 insiders

Sold, 12 months

$0.0M

0 insiders

Of sales under plans

β€”

$0.0M

No open-market insider trades in the last 12 months.

Financial health

Can it carry its debts, and how well does it use its money?

Balance sheet

KIRA Β· Castle Biosciences Inc has $289M more cash than debt.

Cash, debt and the ratios that show how comfortably Castle Biosciences Inc can carry it.

In plain words: What the company owns and what it owes. More cash than debt is a cushion for bad times; a lot of debt leaves less room when business slows down.

Cash vs debt (incl. leases)

Cash Debt
Fiscal year endFY21FY22FY23FY24FY25
Cash and short-term investments $330M$259M$243M$293M$300M
Debt incl. finance leases β€”β€”$0.1M$10.4M$10.5M
Net debt / EBITDA β€”β€”β€”βˆ’11.5xβ€”
Debt / equity β€”β€”0.0x0.0x0.0x
Interest coverage βˆ’40,079.0xβˆ’4,285.6xβˆ’6,179.7x15.0xβˆ’497.8x
Current ratio 14.2x8.1x6.2x7.3x5.3x
Quick ratio 14.1x8.0x6.0x7.1x5.1x
Total assets $463M$447M$453M$531M$579M
Total liabilities $50.8M$48.2M$62.1M$75.4M$108M
Shareholders' equity $412M$399M$391M$456M$471M
Net debt (βˆ’ = net cash) β€”β€”βˆ’$243Mβˆ’$283Mβˆ’$289M

Returns on capital

KIRA Β· Its return on capital was βˆ’18.6%: every 100 invested in the business earned about βˆ’19 in a year.

After-tax operating income as a share of the money invested in the business: debt plus equity, minus cash.

In plain words: How much profit the business makes on the money put into it. A higher percentage means each dollar invested works harder.

Return on capital, equity and assets (annual)

Return on capital Return on equity Return on assets

Piotroski F-score

KIRA Β· Castle Biosciences Inc passes 4 of 9 financial health tests (Piotroski F-score).

Nine pass/fail tests of profitability, funding and efficiency. 8–9 is strong, 0–2 weak.

In plain words: Nine yes/no tests of financial health, one point each. A green tick is a pass: 7 to 9 points is solid, 0 to 3 is weak.

TestFY18FY19FY20FY21FY22FY23FY24FY25
Net income is positive βœ• βœ“ βœ• βœ• βœ• βœ• βœ“ βœ•
Cash from operations is positive βœ• βœ“ βœ“ βœ• βœ• βœ• βœ“ βœ“
Return on assets rose β€” βœ“ βœ• βœ• βœ• βœ“ βœ“ βœ•
Cash from operations exceeds net income βœ• βœ“ βœ“ βœ“ βœ“ βœ“ βœ“ βœ“
Debt fell relative to assets β€” βœ“ βœ“ β€” β€” β€” βœ• βœ“
Current ratio rose β€” βœ“ βœ“ βœ• βœ• βœ• βœ“ βœ•
Share count didn't rise β€” βœ• βœ• βœ• βœ• βœ• βœ• βœ“
Gross margin rose β€” βœ“ βœ• βœ• βœ• βœ“ βœ“ βœ•
Revenue rose relative to assets β€” βœ• βœ• βœ“ βœ“ βœ“ βœ“ βœ•
F-score β€” / 37 / 94 / 92 / 82 / 84 / 87 / 94 / 9
Accruals ratio 26.5%βˆ’2.4%βˆ’7.2%βˆ’2.7%βˆ’5.6%βˆ’11.5%βˆ’9.5%βˆ’15.9%
Altman Z'' βˆ’8.017.1224.0011.9310.197.639.076.15

All figures

Every number, year by year.

8 years of figures

Amounts in USD. Hover a ratio’s name for its definition.

In plain words: Every number we have, year by year. Download it as a spreadsheet if you want to dig deeper.

Download CSV
Fiscal yearFY18FY19FY20FY21FY22FY23FY24FY25
Income statement
Revenue $22.8M $51.9M $62.6M $94.1M $137M $220M $332M $344M
Gross profit $17.5M $44.6M $53.0M $78.3M $105M $175M $272M $273M
Research and development $4.9M $7.4M $13.3M $29.6M $44.9M $53.6M $52.0M $51.9M
Operating income βˆ’$3.8M $7.3M βˆ’$6.5M βˆ’$40.1M βˆ’$72.9M βˆ’$68.0M $8.7M βˆ’$42.8M
Interest expense $2.3M $4.6M $2.6M $0.0M $0.0M $0.0M $0.6M $0.1M
Income tax $0.0M $0.1M $0.1M βˆ’$8.7M βˆ’$1.8M $0.1M $3.3M βˆ’$5.4M
Net income βˆ’$6.4M $5.3M βˆ’$10.3M βˆ’$31.3M βˆ’$67.1M βˆ’$57.5M $18.2M βˆ’$24.2M
Net income to common βˆ’$10.2M $3.0M βˆ’$10.3M β€” β€” β€” β€” β€”
Diluted EPS βˆ’$5.33 βˆ’$0.21 βˆ’$0.54 βˆ’$1.24 βˆ’$2.58 βˆ’$2.14 $0.62 βˆ’$0.83
Diluted shares 0.00B 0.01B 0.02B 0.03B 0.03B 0.03B 0.03B 0.03B
Cash flow
Cash from operations βˆ’$12.3M $7.0M $9.9M βˆ’$19.0M βˆ’$41.7M βˆ’$5.6M $64.9M $64.3M
Capital expenditure $0.3M $0.9M $4.8M $3.5M $5.6M $13.6M $28.3M $36.0M
Free cash flow βˆ’$12.6M $6.1M $5.1M βˆ’$22.5M βˆ’$47.3M βˆ’$19.2M $36.5M $28.3M
Depreciation and amortization $0.3M $0.4M $0.5M $3.4M $10.5M $12.3M $16.0M $40.8M
Stock-based compensation $0.3M $1.2M $8.3M $21.7M $36.3M $51.2M $50.3M $45.9M
Acquisitions β€” β€” β€” $0.0M $27.0M $0.0M $0.0M β€”
Balance sheet
Cash and short-term investments $4.5M $98.8M $410M $330M $259M $243M $293M $300M
Total debt $24.5M $26.7M $0.0M β€” β€” $0.0M $10.0M $10.1M
Finance lease liabilities β€” β€” β€” $0.2M $0.2M $0.1M $0.4M $0.4M
Current assets $18.1M $117M $430M $354M $292M $296M $360M $361M
Current liabilities $6.7M $15.3M $20.9M $24.9M $36.1M $47.7M $49.4M $68.7M
Inventory $0.9M $1.2M $2.2M $2.0M $4.0M $7.9M $8.1M $10.3M
Property and equipment, net $1.5M $2.1M $7.1M $9.5M $14.3M β€” β€” β€”
Goodwill β€” β€” β€” $0.0M $10.7M $10.7M $10.7M $10.7M
Intangible assets $0.0M $0.0M $0.0M $88.9M $116M $107M $95.5M $88.9M
Total assets $22.4M $120M $439M $463M $447M $453M $531M $579M
Total liabilities $32.5M $34.6M $23.6M $50.8M $48.2M $62.1M $75.4M $108M
Shareholders' equity βˆ’$56.6M $85.1M $416M $412M $399M $391M $456M $471M
Margins
Gross margin 76.8% 85.9% 84.5% 83.2% 76.6% 79.5% 81.9% 79.4%
Operating margin βˆ’16.8% 14.1% βˆ’10.4% βˆ’42.6% βˆ’53.2% βˆ’30.9% 2.6% βˆ’12.4%
EBITDA margin βˆ’15.6% 14.8% βˆ’9.7% βˆ’39.0% βˆ’45.5% βˆ’25.3% 7.4% βˆ’0.6%
Net margin βˆ’27.9% 10.2% βˆ’16.4% βˆ’33.3% βˆ’49.0% βˆ’26.1% 5.5% βˆ’7.0%
FCF margin βˆ’55.2% 11.7% 8.2% βˆ’23.9% βˆ’34.5% βˆ’8.8% 11.0% 8.2%
Returns
Return on capital β€” 44.7% βˆ’88.5% β€” β€” βˆ’36.2% 4.0% βˆ’18.6%
Return on capital employed βˆ’24.5% 7.0% βˆ’1.6% βˆ’9.2% βˆ’17.7% βˆ’16.8% 1.8% βˆ’8.4%
Return on equity β€” 37.0% βˆ’4.1% βˆ’7.6% βˆ’16.6% βˆ’14.5% 4.3% βˆ’5.2%
Return on assets βˆ’28.4% 7.4% βˆ’3.7% βˆ’6.9% βˆ’14.8% βˆ’12.8% 3.7% βˆ’4.4%
Return on tangible equity β€” 3.5% βˆ’2.5% βˆ’9.7% βˆ’24.6% βˆ’21.0% 5.2% βˆ’6.5%
Growth
Revenue growth β€” 127.6% 20.8% 50.2% 45.7% 60.4% 51.1% 3.7%
Net income growth β€” β€” βˆ’294.9% β€” β€” β€” β€” βˆ’232.4%
EPS growth β€” β€” β€” β€” β€” β€” β€” βˆ’233.9%
FCF growth β€” β€” βˆ’15.9% βˆ’539.3% β€” β€” β€” βˆ’22.5%
Share count change β€” 354.2% 118.6% 32.8% 3.6% 2.9% 9.2% βˆ’0.9%
Financial health
Net debt / EBITDA β€” βˆ’9.4x β€” β€” β€” β€” βˆ’11.5x β€”
Debt / equity β€” 0.3x 0.0x β€” β€” 0.0x 0.0x 0.0x
Interest coverage βˆ’1.7x 1.6x βˆ’2.5x βˆ’40,079.0x βˆ’4,285.6x βˆ’6,179.7x 15.0x βˆ’497.8x
Current ratio 2.7x 7.6x 20.6x 14.2x 8.1x 6.2x 7.3x 5.3x
Quick ratio 2.6x 7.6x 20.5x 14.1x 8.0x 6.0x 7.1x 5.1x
Capital allocation
Capex / revenue 1.2% 1.8% 7.6% 3.7% 4.1% 6.2% 8.5% 10.5%
Stock comp / revenue 1.3% 2.4% 13.3% 23.1% 26.5% 23.3% 15.2% 13.3%
Quality scores
Piotroski F-score β€” 7.0 4.0 2.0 2.0 4.0 7.0 4.0
Altman Z'' βˆ’8.0 7.1 24.0 11.9 10.2 7.6 9.1 6.1
Accruals ratio 26.5% βˆ’2.4% βˆ’7.2% βˆ’2.7% βˆ’5.6% βˆ’11.5% βˆ’9.5% βˆ’15.9%

Source: SEC EDGAR XBRL filings (CIK 0001447362). Data updated October 24, 2026. Quarterly fourth quarters are the full year minus the first nine months. For information only β€” not investment advice. Check the original filings before relying on any figure.

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