SPRO Nasdaq Pharmaceutical Preparations Financials FY2016βFY2025
Spero Therapeutics, Inc. had $66.8M of revenue in fiscal 2025, up 39.2% on the year before. Over five years, revenue changed +48.2% a year on average.
Last close Β· Oct 23, 2026
$1.11
1.8%Hi! I read Spero Therapeutics, Inc.βs latest annual report (fiscal 2025). Here is what stands out:
Good So-so Weak
Are sales growing?
+39.2%
Yes. Sales grew 39.2% last year.
Does it make a profit?
12.8%
Yes. It keeps 12.8% of every sale as profit.
How healthy are the accounts?
4 / 7
Mixed. It passes 4 of 7 health tests.
How is the share priced?
7.9x
One share costs 7.9 times its yearly profit per share.
Rules of thumb on reported numbers. A starting point, not a recommendation.
Is it selling more, and how much does it keep?
In plain words: Every quarter, companies publish how much they sold and earned. These are the days Spero Therapeutics, Inc. did it, and the next one. Share prices often move a lot on those days.
Next results
November 12, 2026
Thursday Β· in 18 days
No past results dates on file yet.
KIRA Β· Spero Therapeutics, Inc. had $66.8M of revenue in fiscal 2025, up 39.2% on the year before. Over five years, revenue changed +48.2% a year on average. Its operating margin was 9.5%, up 162.4Β pts: of every 100 in sales, about 9 is left after running the business.
In plain words: Revenue is all the money customers paid. The margins show how many cents of each dollar of sales are left over at each step: after making the product (gross), after running the business (operating) and after everything, tax included (net).
KIRA Β· Spero Therapeutics, Inc. made $8.6M of net profit in fiscal 2025.
Loss periods are shown in red.
In plain words: Net income is the profit left after every cost and tax. Earnings per share (EPS) splits that profit across every share, so it shows what one share earned.
How much cash comes in, and where does it go?
Cash from operations minus capital spending.
In plain words: Profit on paper is not the same as cash in the bank. Free cash flow is the cash left after paying to run and maintain the business: the money it can hand back to shareholders, save or invest.
In plain words: Companies hand cash back in two ways: dividends (cash paid to shareholders) and buybacks (buying back their own shares, so each remaining share owns a bigger slice).
KIRA Β· No open-market insider trades in the last 12 months.
Open-market purchases and sales by officers, directors and 10% owners, from Form 4 filings. βPlanβ marks trades under a pre-arranged Rule 10b5-1 plan.
In plain words: Insiders are the people who run or own a big part of the company. Buying with their own money can signal confidence; selling often has personal reasons, like taxes or diversifying.
Bought, 12 months
$0.0M
0 insiders
Sold, 12 months
$0.0M
0 insiders
Of sales under plans
β
$0.0M
No open-market insider trades in the last 12 months.
Can it carry its debts, and how well does it use its money?
Cash, debt and the ratios that show how comfortably Spero Therapeutics, Inc. can carry it.
In plain words: What the company owns and what it owes. More cash than debt is a cushion for bad times; a lot of debt leaves less room when business slows down.
| Fiscal year end | FY21 | FY22 | FY23 | FY24 | FY25 |
|---|---|---|---|---|---|
| Cash and short-term investments | $146M | $109M | $76.3M | $52.9M | $40.3M |
| Current ratio | 8.5x | 5.2x | 3.5x | 2.2x | 7.6x |
| Quick ratio | 8.5x | 5.2x | 3.5x | 2.2x | 7.6x |
| Total assets | $171M | $125M | $182M | $111M | $68.9M |
| Total liabilities | $82.8M | $48.9M | $75.5M | $64.4M | $9.9M |
| Shareholders' equity | $88.3M | $75.9M | $107M | $46.1M | $59.0M |
| Net debt (β = net cash) | β | β | β | β | β |
After-tax operating income as a share of the money invested in the business: debt plus equity, minus cash.
In plain words: How much profit the business makes on the money put into it. A higher percentage means each dollar invested works harder.
KIRA Β· Spero Therapeutics, Inc. passes 4 of 7 financial health tests (Piotroski F-score).
Nine pass/fail tests of profitability, funding and efficiency. 8β9 is strong, 0β2 weak.
In plain words: Nine yes/no tests of financial health, one point each. A green tick is a pass: 7 to 9 points is solid, 0 to 3 is weak.
| Test | FY16 | FY17 | FY18 | FY19 | FY20 | FY21 | FY22 | FY23 | FY24 | FY25 |
|---|---|---|---|---|---|---|---|---|---|---|
| Net income is positive | β | β | β | β | β | β | β | β | β | β |
| Cash from operations is positive | β | β | β | β | β | β | β | β | β | β |
| Return on assets rose | β | β | β | β | β | β | β | β | β | β |
| Cash from operations exceeds net income | β | β | β | β | β | β | β | β | β | β |
| Debt fell relative to assets | β | β | β | β | β | β | β | β | β | β |
| Current ratio rose | β | β | β | β | β | β | β | β | β | β |
| Share count didn't rise | β | β | β | β | β | β | β | β | β | β |
| Gross margin rose | β | β | β | β | β | β | β | β | β | β |
| Revenue rose relative to assets | β | β | β | β | β | β | β | β | β | β |
| F-score | β / 3 | 2 / 7 | 3 / 7 | 2 / 7 | 2 / 7 | 2 / 7 | 3 / 7 | 3 / 7 | 1 / 7 | 4 / 7 |
| Accruals ratio | 25.2% | 0.7% | β1.9% | β9.3% | 5.8% | β15.7% | β26.1% | 36.3% | β30.8% | 23.6% |
| Altman Z'' | β31.04 | 9.93 | 9.18 | β3.40 | 2.45 | β4.00 | β6.62 | β1.33 | β13.81 | β8.90 |
Every number, year by year.
Amounts in USD. Hover a ratioβs name for its definition.
In plain words: Every number we have, year by year. Download it as a spreadsheet if you want to dig deeper.
| Fiscal year | FY16 | FY17 | FY18 | FY19 | FY20 | FY21 | FY22 | FY23 | FY24 | FY25 |
|---|---|---|---|---|---|---|---|---|---|---|
| Income statement | ||||||||||
| Revenue | $0.3M | $2.0M | $4.0M | $18.1M | $9.3M | $18.3M | $53.5M | $104M | $48.0M | $66.8M |
| Research and development | $26.3M | $32.9M | $33.9M | $65.8M | $67.0M | $64.5M | $47.6M | $51.4M | $96.8M | $38.5M |
| Operating income | β$33.2M | β$41.7M | β$42.8M | β$63.2M | β$79.1M | β$88.0M | β$42.2M | $21.5M | β$73.4M | $6.3M |
| Pretax income | β$32.6M | β$39.9M | β$41.7M | β$60.9M | β$78.3M | β$89.8M | β$46.4M | $25.4M | β$68.6M | $8.8M |
| Income tax | $0.0M | $0.0M | $0.0M | $0.0M | $0.0M | $0.0M | $0.0M | $2.6M | $0.0M | $0.3M |
| Net income | β$25.5M | β$38.7M | β$41.7M | β$60.9M | β$78.3M | β$89.8M | β$46.4M | $22.8M | β$68.6M | $8.6M |
| Net income to common | β$29.9M | β$46.1M | β$41.7M | β$60.9M | β$78.8M | β$89.8M | $46.4M | β | β | β |
| Diluted EPS | β$95.87 | β$17.82 | β$2.60 | β$3.35 | β$3.52 | β$2.91 | β$1.23 | $0.43 | β$1.27 | $0.15 |
| Diluted shares | 0.00B | 0.00B | 0.02B | 0.02B | 0.02B | 0.03B | 0.04B | 0.05B | 0.05B | 0.06B |
| Cash flow | ||||||||||
| Cash from operations | β$29.0M | β$39.1M | β$39.6M | β$50.0M | β$85.9M | β$64.3M | β$7.7M | β$33.0M | β$23.4M | β$12.6M |
| Capital expenditure | $0.8M | $0.0M | $2.4M | $0.3M | $0.2M | β | β | β | β | β |
| Free cash flow | β$29.8M | β$39.1M | β$42.1M | β$50.3M | β$86.0M | β | β | β | β | β |
| Depreciation and amortization | $0.3M | $0.4M | $0.4M | $0.8M | $0.8M | $0.6M | $0.9M | $0.4M | $0.0M | $0.0M |
| Stock-based compensation | $0.2M | $1.4M | $2.7M | $3.8M | $4.9M | $9.4M | $9.1M | $7.9M | $7.8M | $4.3M |
| Balance sheet | ||||||||||
| Cash and short-term investments | $10.3M | $87.3M | $115M | $82.0M | $127M | $146M | $109M | $76.3M | $52.9M | $40.3M |
| Current assets | $11.9M | $92.1M | $124M | $95.4M | $139M | $158M | $114M | $131M | $107M | $67.3M |
| Current liabilities | $6.9M | $8.2M | $12.3M | $26.7M | $14.3M | $18.7M | $21.6M | $37.2M | $49.1M | $8.9M |
| Property and equipment, net | $1.5M | $1.2M | $2.9M | $2.3M | $1.7M | $1.0M | $0.4M | $0.0M | $0.0M | β |
| Total assets | $13.8M | $93.5M | $129M | $106M | $153M | $171M | $125M | $182M | $111M | $68.9M |
| Total liabilities | $7.4M | $8.5M | $13.2M | $31.5M | $21.4M | $82.8M | $48.9M | $75.5M | $64.4M | $9.9M |
| Preferred stock | β | β | β | β | $0.0M | $0.0M | $0.0M | $0.0M | $0.0M | $0.0M |
| Shareholders' equity | β$45.4M | $84.6M | $116M | $74.6M | $132M | $88.3M | $75.9M | $107M | $46.1M | $59.0M |
| Margins | ||||||||||
| Operating margin | β9,916.7% | β2,108.6% | β1,079.3% | β348.4% | β847.9% | β481.9% | β78.9% | 20.7% | β152.9% | 9.5% |
| EBITDA margin | β9,833.4% | β2,090.3% | β1,069.0% | β344.2% | β839.8% | β478.3% | β77.2% | 21.1% | β152.9% | 9.5% |
| Net margin | β7,609.3% | β1,957.7% | β1,051.4% | β335.6% | β839.2% | β491.9% | β86.7% | 22.0% | β142.9% | 12.8% |
| FCF margin | β8,892.2% | β1,977.7% | β1,060.5% | β277.4% | β922.1% | β | β | β | β | β |
| Returns | ||||||||||
| Return on capital employed | β484.7% | β48.9% | β36.7% | β79.6% | β56.9% | β57.7% | β40.9% | 14.8% | β119.3% | 10.5% |
| Return on equity | β | β197.9% | β41.7% | β64.1% | β75.8% | β81.5% | β56.5% | 24.9% | β89.6% | 16.3% |
| Return on assets | β185.1% | β72.2% | β37.5% | β51.8% | β60.3% | β55.3% | β31.4% | 14.8% | β46.8% | 9.6% |
| Return on tangible equity | β | β54.5% | β36.1% | β81.7% | β59.7% | β101.7% | 61.1% | 21.3% | β148.7% | 14.5% |
| Growth | ||||||||||
| Revenue growth | β | 490.7% | 100.4% | 357.6% | β48.6% | 95.7% | 193.1% | 94.0% | β53.8% | 39.2% |
| Net income growth | β | β | β | β | β | β | β | β | β400.6% | β |
| EPS growth | β | β | β | β | β | β | β | β | β395.3% | β |
| Share count change | β | 728.6% | 518.6% | 13.5% | 23.3% | 38.0% | 21.7% | 41.0% | 2.0% | 9.3% |
| Financial health | ||||||||||
| Current ratio | 1.7x | 11.3x | 10.1x | 3.6x | 9.7x | 8.5x | 5.2x | 3.5x | 2.2x | 7.6x |
| Quick ratio | 1.7x | 11.3x | 10.1x | 3.6x | 9.7x | 8.5x | 5.2x | 3.5x | 2.2x | 7.6x |
| Capital allocation | ||||||||||
| Capex / revenue | 247.8% | 1.4% | 61.4% | 1.7% | 1.7% | β | β | β | β | β |
| Stock comp / revenue | 53.7% | 72.1% | 69.3% | 20.8% | 52.4% | 51.7% | 17.0% | 7.6% | 16.2% | 6.5% |
| Quality scores | ||||||||||
| Piotroski F-score | β | 2.0 | 3.0 | 2.0 | 2.0 | 2.0 | 3.0 | 3.0 | 1.0 | 4.0 |
| Altman Z'' | β31.0 | 9.9 | 9.2 | β3.4 | 2.4 | β4.0 | β6.6 | β1.3 | β13.8 | β8.9 |
| Accruals ratio | 25.2% | 0.7% | β1.9% | β9.3% | 5.8% | β15.7% | β26.1% | 36.3% | β30.8% | 23.6% |
Source: SEC EDGAR XBRL filings (CIK 0001701108). Data updated October 24, 2026. Quarterly fourth quarters are the full year minus the first nine months. For information only β not investment advice. Check the original filings before relying on any figure.
