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Taysha Gene Therapies, Inc.

TSHA Nasdaq Biological Products, (No Diagnostic Substances) Financials FY2020–FY2025

Taysha Gene Therapies, Inc. had $9.8M of revenue in fiscal 2025, up 17.3% on the year before.

Download report 3-page PDF: the company, its results and charts with peers.

Last close Β· Oct 23, 2026

$3.96

1.1%

What Taysha Gene Therapies, Inc. does

TSHA Β· Biological Products, (No Diagnostic Substances)

From its latest annual report

No business description yet.

Filing details

Legal name
Taysha Gene Therapies, Inc.
Fiscal year ends
December 31, 2025
Latest annual report
10-K Β· Mar 19, 2026
Accession Β· CIK
0001193125-26-115202 Β· 0001806310

KIRA’s summary AI analyst

Hi! I read Taysha Gene Therapies, Inc.’s latest annual report (fiscal 2025). Here is what stands out:

2 strengths 3 to watch

1.Sales and profit

See section β†’
  • Taysha Gene Therapies, Inc. had $9.8M of revenue in fiscal 2025, up 17.3% on the year before.
  • Its operating margin was βˆ’1,130.6%, down 33.1Β pts: of every 100 in sales, about βˆ’1,131 is left after running the business.
  • Taysha Gene Therapies, Inc. lost $109M in fiscal 2025.

Taysha Gene Therapies, Inc. in 30 seconds

Good So-so Weak

Good

Are sales growing?

+17.3%

Yes. Sales grew 17.3% last year.

Weak

Does it make a profit?

βˆ’1,115.3%

No. It lost money last year.

Weak

Does profit turn into cash?

βˆ’960.1%

No. It spent more cash than it brought in.

So-so

How healthy are the accounts?

4 / 8

Mixed. It passes 4 of 8 health tests.

For information

How is the share priced?

β€”

No P/E: it made no profit over the last four quarters.

Rules of thumb on reported numbers. A starting point, not a recommendation.

Key numbers, fiscal 2025

Market cap Last close times the latest diluted share count, so it is approximate.
$1.5B
Oct 23 close
P/E Last close divided by diluted earnings per share over the last four quarters.
β€”
On βˆ’$0.42 EPS (TTM)

Revenue

Total sales reported in the income statement.

KIRA Β· Taysha Gene Therapies, Inc. had $9.8M of revenue in fiscal 2025, up 17.3% on the year before.

See the full section β†’

Operating margin

Operating income as a share of revenue.

KIRA Β· Its operating margin was βˆ’1,130.6%, down 33.1Β pts: of every 100 in sales, about βˆ’1,131 is left after running the business.

See the full section β†’

Net income

Profit after all expenses, interest and tax.

KIRA Β· Taysha Gene Therapies, Inc. lost $109M in fiscal 2025.

See the full section β†’

Free cash flow

Cash from operations minus capital spending.

KIRA Β· Free cash flow was βˆ’$93.8M in fiscal 2025, βˆ’960.1% of revenue.

See the full section β†’

Return on capital

After-tax operating income as a share of the money invested in the business: debt plus equity, minus cash.

Sales and profit

Is it selling more, and how much does it keep?

Results dates

In plain words: Every quarter, companies publish how much they sold and earned. These are the days Taysha Gene Therapies, Inc. did it, and the next one. Share prices often move a lot on those days.

Next results

November 3, 2026

Tuesday Β· in 8 days

Time
Time not announced
Covers
Period ended Sep 30, 2026
Expected EPS
βˆ’$0.14
Source
Earnings calendar
See who else reports that week β†’
Date Results for Time Source
Aug 11, 2026 Q2 '26 After the market closes 8-K β†—
May 6, 2026 Q1 '26 Before the market opens 8-K β†—
Mar 19, 2026 Q4 '25 Before the market opens 8-K β†—
Nov 4, 2025 Q3 '25 Before the market opens 8-K β†—
Aug 12, 2025 Q2 '25 Before the market opens 8-K β†—
May 15, 2025 Q1 '25 Before the market opens 8-K β†—
Feb 26, 2025 Q4 '24 Before the market opens 8-K β†—
Nov 13, 2024 Q3 '24 After the market closes 8-K β†—

From SEC filings: the results press release (8-K) or, without one, the quarterly or annual report.

Revenue and margins

KIRA Β· Taysha Gene Therapies, Inc. had $9.8M of revenue in fiscal 2025, up 17.3% on the year before. Its operating margin was βˆ’1,130.6%, down 33.1Β pts: of every 100 in sales, about βˆ’1,131 is left after running the business.

In plain words: Revenue is all the money customers paid. The margins show how many cents of each dollar of sales are left over at each step: after making the product (gross), after running the business (operating) and after everything, tax included (net).

Revenue

Revenue

Margins, % of revenue

Gross Operating Net FCF

Margins, % of revenue

Gross Operating Net FCF

Net income and earnings per share

KIRA Β· Taysha Gene Therapies, Inc. lost $109M in fiscal 2025.

Loss periods are shown in red.

In plain words: Net income is the profit left after every cost and tax. Earnings per share (EPS) splits that profit across every share, so it shows what one share earned.

Net income

Net income

Diluted EPS

Diluted EPS

Cash and shareholders

How much cash comes in, and where does it go?

Cash flow

KIRA Β· Free cash flow was βˆ’$93.8M in fiscal 2025, βˆ’960.1% of revenue.

Cash from operations minus capital spending.

In plain words: Profit on paper is not the same as cash in the bank. Free cash flow is the cash left after paying to run and maintain the business: the money it can hand back to shareholders, save or invest.

Free cash flow

Free cash flow

Cash from operations vs capital spending

Cash from operations Capital spending

Cash from operations vs capital spending

Cash from operations Capital spending

Dividends, buybacks and share count

In plain words: Companies hand cash back in two ways: dividends (cash paid to shareholders) and buybacks (buying back their own shares, so each remaining share owns a bigger slice).

Dividends and buybacks

Dividends Buybacks

Diluted shares outstanding (annual)

Insider trades

KIRA Β· No open-market insider trades in the last 12 months.

Open-market purchases and sales by officers, directors and 10% owners, from Form 4 filings. β€œPlan” marks trades under a pre-arranged Rule 10b5-1 plan.

In plain words: Insiders are the people who run or own a big part of the company. Buying with their own money can signal confidence; selling often has personal reasons, like taxes or diversifying.

Bought, 12 months

$0.0M

0 insiders

Sold, 12 months

$0.0M

0 insiders

Of sales under plans

β€”

$0.0M

No open-market insider trades in the last 12 months.

Financial health

Can it carry its debts, and how well does it use its money?

Balance sheet

KIRA Β· Taysha Gene Therapies, Inc. has $269M more cash than debt.

Cash, debt and the ratios that show how comfortably Taysha Gene Therapies, Inc. can carry it.

In plain words: What the company owns and what it owes. More cash than debt is a cushion for bad times; a lot of debt leaves less room when business slows down.

Cash vs debt (incl. leases)

Cash Debt
Fiscal year endFY21FY22FY23FY24FY25
Cash and short-term investments $149M$87.9M$144M$139M$320M
Debt incl. finance leases $37.2M$39.4M$41.6M$44.7M$50.5M
Debt / equity 0.4x40.0x0.5x0.6x0.2x
Interest coverage βˆ’121.3xβˆ’42.8xβˆ’14.5xβˆ’896.7xβˆ’1,753.9x
Current ratio 3.1x1.5x4.1x5.4x12.2x
Quick ratio 3.1x1.5x4.1x5.4x12.2x
Total assets $214M$126M$173M$160M$343M
Total liabilities $119M$125M$97.8M$88.8M$96.4M
Shareholders' equity $95.4M$0.9M$74.9M$71.5M$247M
Net debt (βˆ’ = net cash) βˆ’$112Mβˆ’$48.5Mβˆ’$102Mβˆ’$94.3Mβˆ’$269M

Returns on capital

After-tax operating income as a share of the money invested in the business: debt plus equity, minus cash.

In plain words: How much profit the business makes on the money put into it. A higher percentage means each dollar invested works harder.

Return on capital, equity and assets (annual)

Return on capital Return on equity Return on assets

Piotroski F-score

KIRA Β· Taysha Gene Therapies, Inc. passes 4 of 8 financial health tests (Piotroski F-score).

Nine pass/fail tests of profitability, funding and efficiency. 8–9 is strong, 0–2 weak.

In plain words: Nine yes/no tests of financial health, one point each. A green tick is a pass: 7 to 9 points is solid, 0 to 3 is weak.

TestFY20FY21FY22FY23FY24FY25
Net income is positive βœ• βœ• βœ• βœ• βœ• βœ•
Cash from operations is positive βœ• βœ• βœ• βœ• βœ• βœ•
Return on assets rose β€” βœ• βœ• βœ“ βœ“ βœ“
Cash from operations exceeds net income βœ“ βœ“ βœ“ βœ“ βœ“ βœ“
Debt fell relative to assets β€” β€” βœ• βœ“ βœ• βœ“
Current ratio rose β€” βœ• βœ• βœ“ βœ“ βœ“
Share count didn't rise β€” βœ• βœ• βœ• βœ• βœ•
Gross margin rose β€” β€” β€” β€” β€” β€”
Revenue rose relative to assets β€” β€” β€” βœ“ βœ• βœ•
F-score β€” / 3β€” / 61 / 75 / 83 / 84 / 8
Accruals ratio βˆ’11.3%βˆ’24.3%βˆ’45.6%βˆ’25.8%βˆ’4.8%βˆ’6.3%
Altman Z'' 39.28βˆ’4.88βˆ’17.25βˆ’7.40βˆ’10.49βˆ’0.53

All figures

Every number, year by year.

6 years of figures

Amounts in USD. Hover a ratio’s name for its definition.

In plain words: Every number we have, year by year. Download it as a spreadsheet if you want to dig deeper.

Download CSV
Fiscal yearFY20FY21FY22FY23FY24FY25
Income statement
Revenue β€” β€” $2.5M $15.5M $8.3M $9.8M
Research and development $31.9M $132M $91.2M $56.8M $66.0M $86.4M
Operating income βˆ’$43.0M βˆ’$173M βˆ’$162M βˆ’$72.4M βˆ’$91.5M βˆ’$110M
Interest expense $0.0M $1.4M $3.8M $5.0M $0.1M $0.1M
Income tax $0.0M β€” $0.0M $0.0M $0.0M $0.0M
Net income βˆ’$60.0M βˆ’$175M βˆ’$166M βˆ’$112M βˆ’$89.3M βˆ’$109M
Net income to common βˆ’$60.0M βˆ’$175M βˆ’$166M βˆ’$112M βˆ’$89.3M βˆ’$109M
Diluted EPS βˆ’$3.40 βˆ’$4.64 βˆ’$3.78 βˆ’$0.96 βˆ’$0.36 βˆ’$0.34
Diluted shares 0.02B 0.04B 0.04B 0.12B 0.25B 0.32B
Cash flow
Cash from operations βˆ’$30.7M βˆ’$117M βˆ’$88.4M βˆ’$73.0M βˆ’$81.2M βˆ’$93.1M
Capital expenditure $0.1M $15.3M $20.6M $3.9M $0.4M $0.7M
Free cash flow βˆ’$30.8M βˆ’$132M βˆ’$109M βˆ’$76.9M βˆ’$81.6M βˆ’$93.8M
Depreciation and amortization $0.0M $0.5M $1.2M $1.4M $1.2M $1.1M
Stock-based compensation $3.4M $18.2M $18.0M $7.9M $13.1M $13.3M
Balance sheet
Cash and short-term investments $251M $149M $87.9M $144M $139M $320M
Total debt β€” $37.2M $38.0M $40.5M $43.9M $50.1M
Finance lease liabilities β€” β€” $1.5M $1.1M $0.8M $0.4M
Current assets $258M $160M $96.4M $150M $142M $325M
Current liabilities $7.1M $51.7M $62.8M $36.8M $26.2M $26.6M
Property and equipment, net $0.3M $50.6M $15.0M $10.8M $7.5M $6.7M
Total assets $259M $214M $126M $173M $160M $343M
Total liabilities $7.6M $119M $125M $97.8M $88.8M $96.4M
Shareholders' equity $251M $95.4M $0.9M $74.9M $71.5M $247M
Margins
Operating margin β€” β€” βˆ’6,492.7% βˆ’468.8% βˆ’1,097.6% βˆ’1,130.6%
EBITDA margin β€” β€” βˆ’6,445.8% βˆ’460.0% βˆ’1,082.6% βˆ’1,118.9%
Net margin β€” β€” βˆ’6,635.3% βˆ’722.1% βˆ’1,071.6% βˆ’1,115.3%
FCF margin β€” β€” βˆ’4,356.9% βˆ’497.6% βˆ’979.2% βˆ’960.1%
Returns
Return on capital employed βˆ’17.1% βˆ’106.8% βˆ’255.9% βˆ’53.3% βˆ’68.2% βˆ’34.9%
Return on equity βˆ’23.9% βˆ’100.7% βˆ’344.7% βˆ’294.0% βˆ’121.9% βˆ’68.5%
Return on assets βˆ’23.2% βˆ’73.8% βˆ’97.6% βˆ’74.6% βˆ’53.6% βˆ’43.3%
Return on tangible equity βˆ’23.9% βˆ’183.0% βˆ’17,493.6% βˆ’148.9% βˆ’124.8% βˆ’44.1%
Growth
Revenue growth β€” β€” β€” 517.5% βˆ’46.1% 17.3%
Share count change β€” 113.1% 16.7% 164.2% 115.4% 27.8%
Financial health
Debt / equity β€” 0.4x 40.0x 0.5x 0.6x 0.2x
Interest coverage βˆ’1,535.8x βˆ’121.3x βˆ’42.8x βˆ’14.5x βˆ’896.7x βˆ’1,753.9x
Current ratio 36.2x 3.1x 1.5x 4.1x 5.4x 12.2x
Quick ratio 36.2x 3.1x 1.5x 4.1x 5.4x 12.2x
Capital allocation
Capex / revenue β€” β€” 824.1% 25.0% 4.5% 7.6%
Stock comp / revenue β€” β€” 721.1% 51.2% 157.2% 136.1%
Quality scores
Piotroski F-score β€” β€” 1.0 5.0 3.0 4.0
Altman Z'' 39.3 βˆ’4.9 βˆ’17.3 βˆ’7.4 βˆ’10.5 βˆ’0.5
Accruals ratio βˆ’11.3% βˆ’24.3% βˆ’45.6% βˆ’25.8% βˆ’4.8% βˆ’6.3%

Source: SEC EDGAR XBRL filings (CIK 0001806310). Data updated October 24, 2026. Quarterly fourth quarters are the full year minus the first nine months. For information only β€” not investment advice. Check the original filings before relying on any figure.

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