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Rhythm Pharmaceuticals, Inc.

RYTM Nasdaq Pharmaceutical Preparations Financials FY2016–FY2025

Rhythm Pharmaceuticals, Inc. had $190M of revenue in fiscal 2025, up 45.8% on the year before.

Download report 3-page PDF: the company, its results and charts with peers.

Last close Β· Oct 23, 2026

$89.27

1.8%

What Rhythm Pharmaceuticals, Inc. does

RYTM Β· Pharmaceutical Preparations

From its latest annual report

No business description yet.

Filing details

Legal name
RHYTHM PHARMACEUTICALS, INC.
Fiscal year ends
December 31, 2025
Latest annual report
10-K Β· Feb 26, 2026
Accession Β· CIK
0001628280-26-012399 Β· 0001649904

KIRA’s summary AI analyst

Hi! I read Rhythm Pharmaceuticals, Inc.’s latest annual report (fiscal 2025). Here is what stands out:

2 strengths 3 to watch

1.Sales and profit

See section β†’
  • Rhythm Pharmaceuticals, Inc. had $190M of revenue in fiscal 2025, up 45.8% on the year before.
  • Its operating margin was βˆ’101.2%, up 102.8Β pts: of every 100 in sales, about βˆ’101 is left after running the business.
  • Rhythm Pharmaceuticals, Inc. lost $197M in fiscal 2025.

Rhythm Pharmaceuticals, Inc. in 30 seconds

Good So-so Weak

Good

Are sales growing?

+45.8%

Yes. Sales grew 45.8% last year.

Weak

Does it make a profit?

βˆ’103.6%

No. It lost money last year.

Weak

Does profit turn into cash?

βˆ’61.5%

No. It spent more cash than it brought in.

So-so

How healthy are the accounts?

6 / 9

Mixed. It passes 6 of 9 health tests.

For information

How is the share priced?

β€”

No P/E: it made no profit over the last four quarters.

Rules of thumb on reported numbers. A starting point, not a recommendation.

Key numbers, fiscal 2025

Market cap Last close times the latest diluted share count, so it is approximate.
$6.1B
Oct 23 close
P/E Last close divided by diluted earnings per share over the last four quarters.
β€”
On βˆ’$3.11 EPS (TTM)

Revenue

Total sales reported in the income statement.

KIRA Β· Rhythm Pharmaceuticals, Inc. had $190M of revenue in fiscal 2025, up 45.8% on the year before.

See the full section β†’

Operating margin

Operating income as a share of revenue.

KIRA Β· Its operating margin was βˆ’101.2%, up 102.8Β pts: of every 100 in sales, about βˆ’101 is left after running the business.

See the full section β†’

Net income

Profit after all expenses, interest and tax.

KIRA Β· Rhythm Pharmaceuticals, Inc. lost $197M in fiscal 2025.

See the full section β†’

Free cash flow

Cash from operations minus capital spending.

KIRA Β· Free cash flow was βˆ’$117M in fiscal 2025, βˆ’61.5% of revenue.

See the full section β†’

Return on capital

After-tax operating income as a share of the money invested in the business: debt plus equity, minus cash.

Sales and profit

Is it selling more, and how much does it keep?

Results dates

In plain words: Every quarter, companies publish how much they sold and earned. These are the days Rhythm Pharmaceuticals, Inc. did it, and the next one. Share prices often move a lot on those days.

Next results

November 3, 2026

Tuesday Β· in 8 days

Time
Before the market opens
Covers
Period ended Sep 30, 2026
Expected EPS
βˆ’$0.68
Source
Earnings calendar
See who else reports that week β†’
Date Results for Time Source
Aug 4, 2026 Q2 '26 Before the market opens 8-K β†—
May 5, 2026 Q1 '26 Before the market opens 8-K β†—
Jan 9, 2026 Q4 '25 Before the market opens 8-K β†—
Nov 4, 2025 Q3 '25 Before the market opens 8-K β†—
Aug 5, 2025 Q2 '25 Before the market opens 8-K β†—
May 7, 2025 Q1 '25 Before the market opens 8-K β†—
Jan 10, 2025 Q4 '24 Before the market opens 8-K β†—
Nov 5, 2024 Q3 '24 After the market closes 8-K β†—

From SEC filings: the results press release (8-K) or, without one, the quarterly or annual report.

Revenue and margins

KIRA Β· Rhythm Pharmaceuticals, Inc. had $190M of revenue in fiscal 2025, up 45.8% on the year before. Its operating margin was βˆ’101.2%, up 102.8Β pts: of every 100 in sales, about βˆ’101 is left after running the business.

In plain words: Revenue is all the money customers paid. The margins show how many cents of each dollar of sales are left over at each step: after making the product (gross), after running the business (operating) and after everything, tax included (net).

Revenue

Revenue

Margins, % of revenue

Gross Operating Net FCF

Margins, % of revenue

Gross Operating Net FCF

Net income and earnings per share

KIRA Β· Rhythm Pharmaceuticals, Inc. lost $197M in fiscal 2025.

Loss periods are shown in red.

In plain words: Net income is the profit left after every cost and tax. Earnings per share (EPS) splits that profit across every share, so it shows what one share earned.

Net income

Net income

Diluted EPS

Diluted EPS

Cash and shareholders

How much cash comes in, and where does it go?

Cash flow

KIRA Β· Free cash flow was βˆ’$117M in fiscal 2025, βˆ’61.5% of revenue.

Cash from operations minus capital spending.

In plain words: Profit on paper is not the same as cash in the bank. Free cash flow is the cash left after paying to run and maintain the business: the money it can hand back to shareholders, save or invest.

Free cash flow

Free cash flow

Cash from operations vs capital spending

Cash from operations Capital spending

Cash from operations vs capital spending

Cash from operations Capital spending

Dividends, buybacks and share count

In plain words: Companies hand cash back in two ways: dividends (cash paid to shareholders) and buybacks (buying back their own shares, so each remaining share owns a bigger slice).

Dividends and buybacks

Dividends Buybacks

Diluted shares outstanding (annual)

Insider trades

KIRA Β· No open-market insider trades in the last 12 months.

Open-market purchases and sales by officers, directors and 10% owners, from Form 4 filings. β€œPlan” marks trades under a pre-arranged Rule 10b5-1 plan.

In plain words: Insiders are the people who run or own a big part of the company. Buying with their own money can signal confidence; selling often has personal reasons, like taxes or diversifying.

Bought, 12 months

$0.0M

0 insiders

Sold, 12 months

$0.0M

0 insiders

Of sales under plans

β€”

$0.0M

No open-market insider trades in the last 12 months.

Financial health

Can it carry its debts, and how well does it use its money?

Balance sheet

KIRA Β· Rhythm Pharmaceuticals, Inc. has $281M more cash than debt.

Cash, debt and the ratios that show how comfortably Rhythm Pharmaceuticals, Inc. can carry it.

In plain words: What the company owns and what it owes. More cash than debt is a cushion for bad times; a lot of debt leaves less room when business slows down.

Cash vs debt (incl. leases)

Cash Debt
Fiscal year endFY21FY22FY23FY24FY25
Cash and short-term investments $295M$333M$276M$321M$389M
Debt incl. finance leases β€”β€”$106M$110M$108M
Debt / equity β€”β€”0.6x5.1x0.8x
Interest coverage β€”βˆ’34.4xβˆ’13.3xβˆ’12.9xβˆ’9.3x
Current ratio 7.1x8.9x5.6x3.2x4.4x
Quick ratio 7.1x8.8x5.4x3.1x4.2x
Total assets $330M$382M$333M$392M$480M
Total liabilities $45.4M$118M$163M$228M$210M
Shareholders' equity $284M$264M$170M$21.7M$139M
Net debt (βˆ’ = net cash) β€”β€”βˆ’$170Mβˆ’$211Mβˆ’$281M

Returns on capital

After-tax operating income as a share of the money invested in the business: debt plus equity, minus cash.

In plain words: How much profit the business makes on the money put into it. A higher percentage means each dollar invested works harder.

Return on capital, equity and assets (annual)

Return on capital Return on equity Return on assets

Piotroski F-score

KIRA Β· Rhythm Pharmaceuticals, Inc. passes 6 of 9 financial health tests (Piotroski F-score).

Nine pass/fail tests of profitability, funding and efficiency. 8–9 is strong, 0–2 weak.

In plain words: Nine yes/no tests of financial health, one point each. A green tick is a pass: 7 to 9 points is solid, 0 to 3 is weak.

TestFY16FY17FY18FY19FY20FY21FY22FY23FY24FY25
Net income is positive βœ• βœ• βœ• βœ• βœ• βœ• βœ• βœ• βœ• βœ•
Cash from operations is positive βœ• βœ• βœ• βœ• βœ• βœ• βœ• βœ• βœ• βœ•
Return on assets rose β€” βœ“ βœ• βœ• βœ• βœ“ βœ• βœ• βœ• βœ“
Cash from operations exceeds net income βœ“ βœ“ βœ“ βœ“ βœ“ βœ• βœ“ βœ“ βœ“ βœ“
Debt fell relative to assets β€” β€” β€” β€” β€” β€” β€” β€” βœ“ βœ“
Current ratio rose β€” βœ“ βœ• βœ• βœ• βœ• βœ“ βœ• βœ• βœ“
Share count didn't rise β€” βœ• βœ• βœ• βœ• βœ• βœ• βœ• βœ• βœ•
Gross margin rose β€” β€” β€” β€” β€” β€” βœ“ βœ• βœ“ βœ“
Revenue rose relative to assets β€” βœ• βœ• βœ• βœ• βœ“ βœ“ βœ“ βœ“ βœ“
F-score β€” / 33 / 71 / 71 / 71 / 72 / 74 / 82 / 84 / 96 / 9
Accruals ratio βˆ’21.5%βˆ’5.2%βˆ’5.8%βˆ’6.3%βˆ’4.8%29.6%βˆ’2.2%βˆ’13.6%βˆ’40.5%βˆ’18.5%
Altman Z'' βˆ’37.7224.3020.3710.021.343.15βˆ’1.46βˆ’6.41βˆ’9.72βˆ’6.24

All figures

Every number, year by year.

10 years of figures

Amounts in USD. Hover a ratio’s name for its definition.

In plain words: Every number we have, year by year. Download it as a spreadsheet if you want to dig deeper.

Download CSV
Fiscal yearFY16FY17FY18FY19FY20FY21FY22FY23FY24FY25
Income statement
Revenue $0.0M $0.0M $0.0M $0.0M $0.0M $3.2M $23.6M $77.4M $130M $190M
Gross profit β€” β€” β€” β€” β€” $2.6M $21.5M $68.1M $117M $170M
Research and development $19.6M $22.9M $50.3M $109M $90.5M $104M $109M $135M $238M $167M
Operating income βˆ’$25.9M βˆ’$32.4M βˆ’$78.4M βˆ’$146M βˆ’$137M βˆ’$170M βˆ’$179M βˆ’$184M βˆ’$266M βˆ’$192M
Interest expense β€” β€” β€” β€” β€” β€” $5.2M $13.9M $20.6M $20.6M
Pretax income β€” β€” β€” β€” β€” βˆ’$69.6M βˆ’$181M βˆ’$184M βˆ’$260M βˆ’$196M
Income tax β€” β€” β€” β€” β€” β€” β€” $0.6M $0.3M $0.5M
Net income βˆ’$25.9M βˆ’$33.7M βˆ’$74.1M βˆ’$141M βˆ’$134M βˆ’$69.6M βˆ’$181M βˆ’$185M βˆ’$261M βˆ’$197M
Net income to common βˆ’$29.1M βˆ’$37.6M βˆ’$74.1M βˆ’$141M βˆ’$134M β€” βˆ’$181M βˆ’$185M βˆ’$265M βˆ’$202M
Diluted EPS βˆ’$2.85 βˆ’$2.83 βˆ’$2.39 βˆ’$3.86 βˆ’$3.04 βˆ’$1.40 βˆ’$3.47 βˆ’$3.20 βˆ’$4.34 βˆ’$3.11
Diluted shares 0.01B 0.01B 0.03B 0.04B 0.04B 0.05B 0.05B 0.06B 0.06B 0.06B
Cash flow
Cash from operations βˆ’$23.2M βˆ’$29.5M βˆ’$62.1M βˆ’$123M βˆ’$122M βˆ’$146M βˆ’$173M βˆ’$136M βˆ’$114M βˆ’$116M
Capital expenditure $1.1M $0.1M $0.7M $3.4M $0.2M $0.4M $0.3M $0.0M $0.0M $1.0M
Free cash flow βˆ’$24.3M βˆ’$29.6M βˆ’$62.8M βˆ’$126M βˆ’$122M βˆ’$146M βˆ’$174M βˆ’$136M βˆ’$114M βˆ’$117M
Depreciation and amortization $0.1M $0.2M $0.4M $0.8M $0.7M $0.8M $0.9M $0.9M $0.7M $0.5M
Stock-based compensation $1.2M $2.3M $6.4M $11.9M $17.5M $20.8M $19.8M $32.6M $39.7M $66.8M
Balance sheet
Cash and short-term investments $6.5M $34.2M $49.5M $292M $173M $295M $333M $276M $321M $389M
Total debt β€” β€” β€” β€” β€” β€” β€” $106M $110M $108M
Current assets $11.2M $151M $259M $302M $182M $308M $354M $308M $374M $467M
Current liabilities $4.7M $6.7M $13.6M $24.4M $18.0M $43.4M $39.8M $55.2M $116M $106M
Inventory β€” β€” β€” β€” β€” $0.1M $2.9M $8.6M $18.7M $25.8M
Property and equipment, net $0.9M $0.8M $1.1M $3.7M $3.2M $2.8M $2.2M $1.3M $0.6M $1.1M
Intangible assets β€” β€” β€” β€” β€” $4.7M $7.9M $7.0M $6.2M $5.3M
Total assets $12.3M $152M $260M $309M $187M $330M $382M $333M $392M $480M
Total liabilities $5.0M $6.9M $14.0M $27.5M $20.5M $45.4M $118M $163M $228M $210M
Preferred stock β€” β€” β€” β€” β€” β€” β€” β€” β€” $0.0M
Shareholders' equity βˆ’$32.7M $145M $246M $281M $167M $284M $264M $170M $21.7M $139M
Margins
Gross margin β€” β€” β€” β€” β€” 81.0% 91.0% 88.0% 89.7% 89.7%
Operating margin β€” β€” β€” β€” β€” βˆ’5,391.9% βˆ’757.9% βˆ’238.1% βˆ’204.0% βˆ’101.2%
EBITDA margin β€” β€” β€” β€” β€” βˆ’5,366.0% βˆ’754.1% βˆ’236.9% βˆ’203.5% βˆ’100.9%
Net margin β€” β€” β€” β€” β€” βˆ’2,207.1% βˆ’766.2% βˆ’238.5% βˆ’200.3% βˆ’103.6%
FCF margin β€” β€” β€” β€” β€” βˆ’4,642.9% βˆ’734.9% βˆ’175.9% βˆ’87.5% βˆ’61.5%
Returns
Return on capital β€” β€” β€” β€” β€” β€” β€” βˆ’260,075.1% β€” β€”
Return on capital employed βˆ’340.5% βˆ’22.4% βˆ’31.8% βˆ’51.4% βˆ’80.8% βˆ’59.4% βˆ’52.3% βˆ’66.4% βˆ’95.9% βˆ’51.3%
Return on equity β€” βˆ’60.1% βˆ’37.9% βˆ’53.4% βˆ’59.9% βˆ’30.9% βˆ’66.1% βˆ’85.1% βˆ’272.2% βˆ’244.5%
Return on assets βˆ’209.7% βˆ’41.1% βˆ’36.0% βˆ’49.5% βˆ’54.1% βˆ’27.0% βˆ’50.9% βˆ’51.6% βˆ’71.9% βˆ’45.1%
Return on tangible equity β€” βˆ’26.0% βˆ’30.1% βˆ’50.1% βˆ’80.5% βˆ’24.9% βˆ’70.6% βˆ’113.5% βˆ’1,700.9% βˆ’151.0%
Growth
Revenue growth β€” β€” β€” β€” β€” β€” 649.5% 227.6% 68.1% 45.8%
Share count change β€” 30.1% 133.7% 17.5% 21.2% 12.4% 5.1% 10.7% 5.8% 6.5%
Financial health
Debt / equity β€” β€” β€” β€” β€” β€” β€” 0.6x 5.1x 0.8x
Interest coverage β€” β€” β€” β€” β€” β€” βˆ’34.4x βˆ’13.3x βˆ’12.9x βˆ’9.3x
Current ratio 2.4x 22.4x 19.0x 12.4x 10.1x 7.1x 8.9x 5.6x 3.2x 4.4x
Quick ratio 2.4x 22.4x 19.0x 12.4x 10.1x 7.1x 8.8x 5.4x 3.1x 4.2x
Capital allocation
Capex / revenue β€” β€” β€” β€” β€” 13.8% 1.2% 0.1% 0.0% 0.5%
Stock comp / revenue β€” β€” β€” β€” β€” 659.6% 83.9% 42.0% 30.5% 35.2%
Quality scores
Piotroski F-score β€” 3.0 1.0 1.0 1.0 2.0 4.0 2.0 4.0 6.0
Altman Z'' βˆ’37.7 24.3 20.4 10.0 1.3 3.1 βˆ’1.5 βˆ’6.4 βˆ’9.7 βˆ’6.2
Accruals ratio βˆ’21.5% βˆ’5.2% βˆ’5.8% βˆ’6.3% βˆ’4.8% 29.6% βˆ’2.2% βˆ’13.6% βˆ’40.5% βˆ’18.5%

Source: SEC EDGAR XBRL filings (CIK 0001649904). Data updated October 24, 2026. Quarterly fourth quarters are the full year minus the first nine months. For information only β€” not investment advice. Check the original filings before relying on any figure.

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